Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection

Table 1 Body weight and liver function before and 1 wk after the sham- or partial hepatectomy-operation

	Sham		PH
	Control	Ethanol	Control	Ethanol
	(n = 7)	(n = 8)	(n = 10)	(n = 10)
Body weight (g)
Before operation	264 ± 7	259 ± 8	247 ± 20	246 ± 26
1 wk after operation	274 ± 28	276 ± 15	257 ± 22	260 ± 25
ALT (U/L)
Before operation	27 ± 2	29 ± 2	29 ± 5	29 ± 6
1 wk after operation	26 ± 3	28 ± 3	28 ± 4	27 ± 5

All values shown are mean ± SD. ALT: Blood alanine aminotransferase level; PH: Partial hepatectomy.

Table 2 Recovery of gene expression from the liver resections

	Before PH	1 wk after PH
Fas (fold change from before PH)	1.0 ± 0.34	0.6 ± 0.22
Srebp-1 (fold change from before PH)	1.0 ± 0.26	1.03 ± 0.20
Ppar-α (fold change from before PH)	1.0 ± 0.43	1.04 ± 0.29
Pai-1 (fold change from before PH)	1.0 ± 0.27	0.87 ± 0.33
Tnf-α (fold change from before PH)	1.0 ± 0.20	0.99 ± 0.11
Adh1 (fold change from before PH)	1.0 ± 0.30	0.40 ± 0.06c

The values from the before PH were normalized to 1-fold. All values shown are mean ± SD (n = 4).

^cP < 0.05 vs the before PH using 2-tailed Student t test. PH: Partial hepatectomy.