Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients

Table 1 Study characteristics

Ref.	Year	Study design	Period	Patients (n) (lap/open)	Age	Investigated outcomes	ITT/AT	NOS
Massie et al[15]	1993	Retrospective	1990-1991	58	> 70	Morbidity	NR	3
				(33/25)
Feldman et al[4]	1994	Prospective database1	1988-1992	2269	> 65	Mortality	NR	4
				(1508/761)
Lucier et al[5]	1995	Prospective database2	1991-1992	3907	> 65 (mean 73.9 lap, 75.4 open)	Morbidity, mortality, cardiac, respiratory	NR	3
				(1769/2138)
Samkoff et al[6]	1995	Prospective database3	1992-1993	63920	> 65	Morbidity, mortality, respiratory	NR	3
				(29731/34189)
Huang et al[16]	1996	RCT	1992-1993	27	> 70	Morbidity, mortality, cardiac, respiratory	NA	NA
				(15/12)
Lujan et al[17]	1998	RCT	1991-1996	264	> 65 [median 71 (65-87) lap, 72 (65-88) open]	Morbidity, mortality, respiratory	NR	NA
				(133/131)
Maxwell et al[18]	1998	Prospective database4	1988-1992	18500	> 80 (mean, 83.9 lap, 84.0 open)	Mortality	NR	4
				(5034/13466)
Pessaux et al[19]	2001	Prospective	1992-1999	139	> 75 [mean 81.9 (75-98) lap, 81.9 (75-93) open]	Morbidity, mortality, cardiac, respiratory	NR	7
				(50/89)
Fisichella et al[20]	2002	Retrospective	1995-1998	35	> 70 (mean 74 ± 2.4 lap, 74 ± 4.1 open)	Morbidity, mortality, cardiac, respiratory	ITT	4
				(24/11)
Chau et al[21]	2002	Retrospective	1994-1999	73	> 75 (mean 79.2 ± 4.2 lap, 80.7 ± 4.6 open)	Morbidity, mortality, cardiac, respiratory	ITT	5
				(31/42)
Moyson et al[22]	2008	Retrospective	1991-2007	100	> 75 [median 83 (75-94)]	Mortality, morbidity	AT	5
				(85/15)
Leardi et al[23]	2009	Retrospective	2000-2006	341	> 70	Morbidity	NR	4
				(258/83)
Tucker et al[7]	2011	Prospective database5	2005-2008	11926	> 65 [median 73.0 (69-79)]	Mortality, morbidity, cardiac, respiratory	AT	4
				(9524/2402)

¹Connecticut Health Information and Management Exchange;

²Medicare database Indiana;

³8-State Medicare Database;

⁴Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project-3;

⁵American College of Surgeons Quality Insurance Program ACS NSQIP. ITT: Intention-to-treat; NOS: None otherwise specified; NA: Not available; NR: Not reported; AT: As treated analysis.

Table 2 Study outcomes

Ref.	Conversion	Mortality	Morbidity	Cardiac	Respiratory
Massie et al[15]	NR	NR	4/33 lap	NR	NR
			19/66 open
Feldman et al[4]	NR	7/1508 lap	NR	NR	NR
		11/761 open
Lucier et al[5]	NR	16/1769 lap	200/1769 lap	17/1769 lap	25/1769 lap
		116/2138 open	354/2138 open	26/2138 open	64/2138 open
Samkoff et al[6]	NR	252/29731 lap	3428/29731 lap	NR	871/29731 lap
		1523/34189 open	7361/34189 open		1751/34189 open
Huang et al[16]	0 /15	0/15 lap	0/15 lap	0/15 lap	0/15 lap
	(0%)	0/12 open	3/12 open	0/12 open	1/12 open
Lujan et al[17]	11/113	0/133 lap	18/133 lap	NR	0/133 lap
	(9.7%)	1/131 open	29/131 open		5/131 open
Maxwell et al[18]	NR	91/5034 lap	NR	NR	NR
		593/13466 open
Pessaux[19]	16/50	0/50 lap	9/50 lap	0/50 lap	1/50 lap
	(32%)	4/89 open	19/89 open	2/89 lap	2/89 open
Fisichella et al[20]	2/24	0/24 lap	3/24 lap	0/24 lap	0/24 lap
	(8.3%)	0/11 open	6/11 open	0/11 open	0/11 open
Chau et al[21]	11/31	0/31 lap	4/31 lap	0/31 lap	1/31 lap
	(35.5%)	3/42 open	17/42 open	4/42 open	6/42 open
Moyson et al[22]	12/85	3/73 lap	19/73 lap	NR	NR
	(14.1%)	5/27 open	14/15 open
Leardi et al[23]	16/158 (10.1%)	NR	12/258 lap	NR	NR
			14/83 open
Tucker et al[7]	728/9529 (7.6%)	67/9524 lap	NR	48/9524 lap	76/9524 lap
		65/2402 open		26/2402 open	87/2402 open

NR: Not reported.