Outcome of endotherapy for pancreas divisum in patients with acute recurrent pancreatitis

Table 1 Clinical and demographic data of 36 patients with pancreas divisum and acute recurrent pancreatitis at the time of the enrollment into the study

	Previous RAP (14 pts)	Recent RAP (22 pts)	P value
Male/female	6/8	7/15	0.72
Age (yr), mean ± SD	52.0 ± 12.6	55.6 ± 10.4	0.35
Episodes of pancreatitis (mean ± SD)	2.8 ± 1.1	3.4 ± 1.2	0.14
Duration of the disease (yr), mean ± SD	3.6 ± 1.9	3.4 ± 1.5	0.73

RAP: Recurrent acute pancreatitis.

Table 2 Follow-up results in 33 patients with pancreas divisum and previous and recent recurrent acute pancreatitisaccording to dilatation or non-dilatation of the main pancreatic duct detected at the time of the enrollment into the study n (%)

	Dorsal duct	AP recurrences	EUS signs of CP
Previous RAP (14 pts)	Dilated (6 pts)	0	4 (66.7)1
	Non-dilated (8 pts)	0	5 (62.5)
	Total	0b	9 (64.3)2
Recent RAP (19 pts)	Dilated (11 pts)	2 (18.2)3	7 (63.6)3
	Non-dilated (8 pts)	3 (37.5)	4 (50.0)
	Total	5 (26.3)	11 (57.9)4

¹Dilated and non-dilated in the previous RAP group: P = NS;

²Previous and recent RAP: P = NS;

^bP < 0.05, endotherapy vs main pancreatic duct dilatation;

³Dilated and non-dilated in the recent RAP group: P = NS;

⁴All five patients with AP recurrences during follow-up developed CP. AP: Acute pancreatitis; EUS: Endoscopic ultrasonography; CP: Chronic pancreatitis; RAP: Recurrent acute pancreatitis; NS: Not significant.

Table 3 Demographics, characteristics of the disease and endoscopic ultrasonography signs of chronic pancreatitis development in patients assigned endotherapy able to achieve dorsal duct drainage n (%)

	Successful endotherapy1(14 pts)	Unsuccessful endotherapy2(5 pts)	P value
Male/female	11/3	4/1	1.0
Age (yr), mean ± SD	55.3 ± 7.9	55.0 ± 21.1	0.5
No. of episodes of AP before study, yr, mean ± SD	3.4 (1.3)	3.4 (1.1)	0.8
Duration of ARP before enrollment (yr), mean ± SD	3.2 (1.6)	3.8 (1.3)	0.3
Duration of post-enrollment follow-up (yr), mean ± SD	4.1 (1.3)	4.8 (1.1)	0.7
EUS signs of CP	6 (42.8)	5 (100)	0.04
Duration of disease between the first attack of AP and the diagnosis of CP (yr), mean ± SD	5.6 (1.3)	6.1 (1.7)	0.7

¹Successful endotherapy: No recurrences of AP in the follow up after one to three ERCP sections;

²Unsuccessful endotherapy: Recurrences of AP after three ERCP sections. AP: Acute pancreatitis; CP: Chronic pancreatitis; ERCP: Endoscopic retrograde cholangiopancreatography.

Table 4 Endoscopic ultrasonography signs of chronic pancreatitis in patients with pancreas divisum and previous or recent recurrent acute pancreatitisin relation to the pancreatic stenting n (%)

Group	Stenting	EUS signs of CP
Previous RAP (14 pts)	0	9 (64.3)
Recent RAP (19 pts)	No/short-term (9 pts)	3 (33.3)1
	Long-term (10 pts)	8 (80)2
	Total	11 (57.9)

¹No/short term stenting and long-term stenting: P = 0.07;

²Three in 5 successful stenting (60%); 5 in 5 unsuccessful stenting. EUS: Endoscopic ultrasonography; CP: Chronic pancreatitis.