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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 14, 2014; 20(46): 17399-17406
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17399
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17399
Table 1 Serum biochemistry with D-galactosamine administration (n = 15)
Indicators | 48 h before administration | 48 h after administration | P |
ALT (U/L) | 28.3 ± 4.7 | 494.2 ± 31.9 | 4.09 × 10-18 |
Ammonia (μmol/L) | 28.9 ± 3.0 | 149.5 ± 12.3 | 3.14 × 10-16 |
TBiL (μmol/L) | 1.2 ± 0.2 | 16.7 ± 2.1 | 1.06 × 10-13 |
TBA (U/L) | 6.0 ± 1.4 | 51.1 ± 7.3 | 2.46 × 10-13 |
BUN (μmol/L) | 3.7 ± 0.9 | 6.2 ± 0.9 | 2.96 × 10-6 |
Cr (μmol/L) | 76.7 ± 5.7 | 133.5 ± 6.2 | 1.66 × 10-12 |
ALB (g/L) | 41.3 ± 1.6 | 37.3 ± 0.6 | 5.86 × 10-8 |
Fischer index | 3.2 ± 0.2 | 2.2 ± 0.1 | 1.49 × 10-11 |
Table 2 Hepatocyte changes with hybrid bioartificial liver support
Indicators | 0 h | 24 h | 48 h | 72 h |
Hepatocytes (n× 109) | 4.1 ± 0.3 | 3.9 ± 0.4 | 3.8 ± 0.3 | 3.0 ± 0.1 |
P | - | 0.3675 | 0.2254 | 0.0239 |
A value | 0.985 ± 0.105 | 0.919 ± 0.048 | 0.751 ± 0.024 | 0.530 ± 0.053 |
P | - | 0.3900 | 0.0610 | 0.0173 |
Table 3 Liver cell function during hybrid bioartificial liver support system support
Table 4 General vital signs of a cynomolgus monkey during treatment
Time (h) | Heart rate (per min) | P | Blood oxygen (%) | P | Respiratory rate (per min) | P | Artery blood pressure (mmHg) | P |
0 | 90.5 ± 3.8 | - | 99.7 ± 0.5 | - | 15.3 ± 1.2 | - | 114.6 ± 4.1 | - |
1 | 94.1 ± 3.4 | 0.000959 | 99.6 ± 0.5 | 0.343436 | 13.9 ± 1.4 | 0.000528 | 117.9 ± 4.8 | 0.000093 |
2 | 92.7 ± 3.8 | 0.005743 | 99.1 ± 0.7 | 0.005121 | 15.4 ± 2.0 | 0.797625 | 116.9 ± 6.4 | 0.102480 |
3 | 98.1 ± 3.1 | 0.000002 | 99.4 ± 0.5 | 0.193422 | 16.8 ± 1.9 | 0.006689 | 110.4 ± 4.5 | 0.003146 |
4 | 91.9 ± 3.8 | 0.271246 | 99.0 ± 0.8 | 0.009535 | 15.2 ± 1.4 | 0.780352 | 110.5 ± 4.8 | 0.002654 |
5 | 89.6 ± 3.5 | 0.330509 | 99.6 ± 0.5 | 0.678310 | 15.5 ± 2.0 | 0.678310 | 108.8 ± 5.9 | 0.002654 |
6 | 91.2 ± 4.6 | 0.381557 | 99.7 ± 0.5 | 1 | 16.4 ± 1.6 | 0.003241 | 113.7 ± 4.7 | 0.261975 |
Average | 92.6 ± 4.4 | - | 99.4 ± 0.6 | - | 15.5 ± 1.8 | - | 113.3 ± 5.8 | - |
Table 5 Survival results
Group | Survived | Survival time | 95%CI |
(n) | (h) | ||
Control (n = 5) | 0 | 112.8 ± 2.06 | 108.76-116.84 |
Experimental (n = 10) | 5 | 128 ± 3.32 | 121.49-134.51 |
- Citation: Zhang Z, Zhao YC, Cheng Y, Jian GD, Pan MX, Gao Y. Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure. World J Gastroenterol 2014; 20(46): 17399-17406
- URL: https://www.wjgnet.com/1007-9327/full/v20/i46/17399.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i46.17399