Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 14, 2014; 20(46): 17368-17375
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17368
Table 1 Indirect evidence for efficacy of hematopoietic stem cell transplantation in inflammatory bowel disease
Ref.SCTOriginal indicationNo./type IBDConditioningResults/remarks
Drakos et al[37]Allo-SCTNHL1/fistulizing CDBCNU/Etoposide, Cy, ara-C and MelphalanRemission/6 mo follow up
Kashyap et al[40]Auto-SCTNHL1/Perianal CDCy,VP16+TBIRemission 7 yr/Crohn’s at age 13 yr ASCT at 20 yr
Lopez-Cubero et al[38]Allo-SCTLeukemia5/CDCy/TBI3 pts has lasting remission
Söderholm et al[41]Auto-SCTAML1/Fistulizing CDCy/TBIRemission 5 yr
Ditschkowski et al[39]Auto-SCTAML/CML/MDS11/7 CD +4 UCVariousRemission in 10/Follow up 34 mo
Anumakonda et al[42]Auto-SCTNHL1/CDCHOPRemission 8 yr/Relapse after 8 yr
Table 2 Direct evidence for efficacy of hematopoietic stem cell transplantation and mesenchymal stem cell transplantation in inflammatory bowel disease
Ref.SCT/MSCTNo. treated/type IBDConditioningResults
Burt et al[44]Auto-HSCT2/Crohn’s, fistulas, CDAI > 250Cy + ATGCDAI,CRP, albumin normalized; remission > 1 yr
Kreisel et al[46]Auto-HSCT1/ileocolic Crohn’sCy + ATG9 mo complete remission
García-Olmo et al[52]Auto-HSCT Adipose tissue1/recurrent rectovaginal fistulasNone necessary3 mo asymptomatic
García-Olmo et al[53]MSCT5/fistulasNone necessaryFollow up 22 mo; 75% healing
Oyama et al[47]Auto-HSCT12/fistula 6, stenosis 3, perianal 4; most have surgeryCy + ATG11 sustained remission (CDAI < 150) after median 18.5 mo; 1 relapse > 15 mo
Cassinotti et al[49]Auto-HSCT4/stenosis, fistulas, bleedingCy + ATGAll clinical remission at 3 m, 1 relapse after 4 mo; Sustained remission in 3 after 16.5 m o
Glocker et al[51]Allo-HSCT1/perianal fistulaAlemtuzumab, fludarabine, treosulfan, thiotepaRemission 2 yr; 9-year-old child
Burt et al[48]Auto-HSCT24/Crohn’sCy + ATG91% remission 1 yr, 57% for 3 yr, 19% for 5 yr
Cassinotti et al[49]Auto-HSCT10/Crohn’sCy + ATG80% remission > 1 yr, 40% > 3 yr and 30% > 5 yr
Hasselblatt et al[50]Auto-HSCT12/Crohn’sCy + G-CSF5 complete remission within 6 m, relapses occurred in 7. Mean follow-up 3.1 yr (range 0.5-10.3)
Forbes et al[54]MSCT, weekly for 4 wk16/Crohn’s disease (CDAI > 250)None necessaryCDAI declined from median 327 to 129 (day 42). Clinical response 12 pts; Clinical remission 8 pts. Endoscopic improvement in 7 pts