Hepatitis B and human immunodeficiency virus co-infection

Table 1 Immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with human immunodeficiency virus[53]

n = 426	IM 20μg x 3	IM 40μg x 4	ID 4μg x 4
	n = 141	n = 145	n = 140
Response rates	65%	82%	77%
At week 28	95%CI: 56%-72%	95%CI: 77%-88%	95%CI: 69%-84%
(Anti-HBs > 10 mIU/mL)		P < 0.001 vs IM 20 × 3	P = 0.02 vs IM 20 × 3
High responders rates	41%	74%	53%
(Anti-HBs > 100 mIU/mL)	95%CI: 33%-50%	95%CI: 66%-81%	95%CI: 44%-61%
		P < 0.001 vs IM 20 × 3	P = 0.06 vs IM 20 × 3

Anti-HBs: Antibody to hepatitis B antigen.