3D conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma

Table 1 Clinical characteristics of 10 included trials

Ref.	Year	Study design	n (CMT/TACE)	Tumor stage	KPS	Child-Pugh Class (A/B/C)	Anticancer drug of TACE
Chia-Hsien Cheng et al[25]	2001	Nonrandomized	33 (17/16)	II, IIIA, IVA	≥ 70	33/0/0	doxorubicin, cisplatin, MMC
Lan et al[24]	2005	Nonrandomized	102 (42/60)	II, III			10-Hydroxycamptothecine, DDP, 5-FU
Li et al[23]	2003	Nonrandomized	82 (41/41)			50/32/0	10-Hydroxycamptothecine, 5-FU, MMC or ADM
Liao et al[22]	2010	Randomized	48 (24/24)	III, IV		34/14/0	5-FU, DDP, ADM
Liu et al[21]	2005	Nonrandomized	114 (54/60)		≥ 70	83/31/0	MMC, ADM, CBP
Shang et al[20]	2007	Nonrandomized	76 (40/36)	T1-2N0M0	≥ 70		5-FU, DDP, ADM or MMC
Shim et al[19]	2005	Nonrandomized	73 (38/35)	III, IVa		65/8/0	doxorubicin
Wu et al[18]	2004	Nonrandomized	81 (41/40)	I, II	≥ 70	55/26/0	MMC, ADM, CBP or DDP
Zeng et al[17]	2004	Nonrandomized	203 (54/149)			158/45/0	5-FU, DDP, MMC
Zhao et al[16]	2006	Randomized	96 (49/47)	T1N0M0, T2N0M0	≥ 70	96/0/0	10-Hydroxycamptothecine, DDP, 5-FU

5-FU: 5-fluorouracil; ADM: Doxorubicin; CBP: Carboplatin; CMT: Combination therapy; KPS: Karnofsky score; MMC: Mitomycin C.

Table 2 Outcomes of the combination therapy and transcatheter arterial chemoembolization alone groups

Ref.	Year	1-yr survival		2-yr survival		3-yr survival
		TACE + 3D-CRT	TACE alone	TACE + 3D-CRT	TACE alone	TACE + 3D-CRT	TACE alone
Chia-Hsien Cheng et al[25]	2001			58.0%	56.0%
Lan et al[24]	2005	57.1%	61.7%	40.5%	30.0%	26.2%	16.7%
Li et al[23]	2003	73.2%	54.8%	58.7%	27.3%	41.9%	12.8%
Liao et al[22]	2010	74.0%	50.0%			30.0%	14.0%
Liu et al[21]	2005	66.5%	53.9%	48.4%	37.2%	37.4%	17.8%
Shang et al[20]	2007	78.0%	50.0%	60.0%	32.0%	34.0%	18.0%
Shim et al[19]	2005			36.8%	14.3%
Wu et al[18]	2004	90.2%	89.7%	75.6%	58.7%	44.6%	24.0%
Zeng et al[17]	2004	71.5%	59.6%	42.3%	26.5%	24.0%	11.1%
Zhao et al[16]	2006	82.0%	55.0%	63.0%	28.0%	43.0%	15.0%

TACE: Transcatheter arterial chemoembolization; 3D-CRT: Three-dimensional conformal radiotherapy.