Endoscopic findings of gastrointestinal involvement in Chinese patients with Behcet’s disease

Table 1 Clinical features of Behcet’s disease patients with gastrointestinal lesions (none had arthritis, vascular or neurological involvement)

Case No.	Gender	Age	ISG	Japan	Abdominal pain	Other GI symptoms	Endoscopic findings	Distribution pattern	Size (cm)	Shape
1	Female	26	-	Incomplete	-	Constipation	Terminal ileum	Multiple	> 1, ≤ 3	Round/oval
2	Male	18	-	Incomplete	+		EU, terminal ileum, CU	Multi-segmental	> 1, ≤ 3	Geographic
3	Male	49	+	Incomplete	+		Terminal ileum, GU	Multi-segmental	> 3, ≤ 5	Volcano
4	Female	35	-	Incomplete	-		Terminal ileum	Single	≤ 1	Round/oval
5	Male	23	+	Incomplete	+		Terminal ileum	Single	> 1, ≤ 3	Round/oval
6	Female	22	+	Incomplete	+	Diarrhea	Terminal ileum, CU	Diffuse	> 1, ≤ 3	Geographic
7	Female	32	+	Suspected	+		Ileocecal valve	Single	≤ 1	Round/oval
8	Male	19	-	Suspected	+	Diarrhea	Ileocecal valve	Single	> 3, ≤ 5	Volcano
9	Male	56	+	Incomplete	+	Bloody stool	Terminal ileum	Single	> 1, ≤ 3	Round/oval
10	Female	30	+	Suspected	+		Terminal ileum	Single	> 1, ≤ 3	Round/oval
11	Female	23	+	Incomplete	-		Cecum	Multiple	≤ 1	Round/oval
12	Female	21	+	Incomplete	-		Terminal ileum	Single	> 1, ≤ 3	Round/oval
13	Female	28	+	Incomplete	+	Diarrhea	Ileocecal valve	Single	> 5	Round/oval
14	Male	60	+	Incomplete	+	Diarrhea	Cecum	Single	> 5	Volcano
15	Female	23	+	Incomplete	-		Terminal ileum	Multiple	≤ 1	Round/oval
16	Male	50	+	Incomplete	+	Diarrhea	EU, cecum	Multi-segmental	> 3, ≤ 5	Volcano
17	Male	40	-	Suspected	+	Diarrhea	Terminal ileum	Multiple	> 1, ≤ 3	Volcano
18	Female	58	+	Incomplete	+	Diarrhea	Cecum, CU	Multi-segmental	> 3, ≤ 5	Geographic

GI: Gastrointestinal; EU: Esophageal ulcer; GU: Gastric ulcer; CU: Colonic ulcer; ISG: International Study Group criteria; Japan: Criteria of the Research Committee of Japan 1987.

Table 2 Comparison of symptoms and laboratory findings in Behcet’s disease patients with lower gastrointestinal ulcer(s) and without gastrointestinal lesion n (%)

	BD with lower GI ulcer (n = 20)	BD without GI lesion (n = 96)	P value
Age at diagnosis of intestinal BD (yr)	34.65 ± 14.59	33.63 ± 11.50	0.77
Male (%)	8 (40)	53 (55.2)	-
Duration (mo)	104.30 ± 125.44	88.05 ± 70.13	0.58
Systematic signs
Oral ulcer	20 (100)	96 (100)	1.00
Genital ulcer	16 (80)	69 (72)	0.46
Ocular lesion	0 (0)	27 (28)	< 0.01a
Skin lesion	15 (75)	62 (65)	0.36
Arthralgia	3 (15)	30 (31)	0.10
Epididymitis	0 (0)	1 (1)	0.65
Pathergy test	4 (20)	20 (21)	0.95
Vasculitis	0 (0)	2 (2)	0.52
Central nerve system	0 (0)	1 (1)	0.65
Laboratory findings at diagnosis
CRP (mg/L)	30.34 ± 30.62	12.41 ± 9.18	0.02a
ESR (mm/h)	36.75 ± 22.65	24.04 ± 23.50	0.03a
Albumin (g/L)	38.70 ± 4.00	42.71 ± 6.12	< 0.01a
WBC (109/L)	7.00 ± 2.78	7.46 ± 2.69	0.49
RBC (1012/L)	4.13 ± 0.46	4.62 ± 0.64	0.02a
Hemoglobin (g/L)	117.47 ± 15.11	137.81 ± 18.29	< 0.01a
Platelets (109/L)	249.65 ± 92.49	240.54 ± 73.60	0.63

^aP < 0.05 vs control. BD: Behcet’s disease; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; WBC: White blood cell count; RBC: Red blood cell count; GI: Gastrointestinal.