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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 7, 2014; 20(45): 17100-17106
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17100
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17100
Table 1 Loci distribution of adefovir dipivoxil -resistant mutants n (%)
ADV-resistant mutants | Number of patients | prevalence of patients |
rtA181T12 mutant/coexisting mutants3 | 40 (50.63) | |
rtV214A1 mutant/coexisting mutants | 7 (8.86) | |
rtN236T1 mutant/coexisting mutants | 5 (6.33) | |
rtP237H1 mutant | 1 (1.27) | |
rtL180M4 + rtM204V456 + rtA181T12 coexisting mutants | 4 (5.06) | |
rtL180M4 + rtT184L6 coexisting mutants, rtM204V45 + rtV207M/L/I4 + rtV214A1 mutant | 1 (1.27) | |
rtL180M4 + rtM204V456 + rtS213T4 + rtA181T12 mutant | 1 (1.27) | |
rtL180M4 + rtM204V456 + rtS213T4 + rtQ215S1 mutant, rtP237H1 coexisting mutants | 1 (1.27) | |
rtL180M4 + rtM204V456 + rtQ215S1 + rtT184L6 mutant | 1 (1.27) | |
rtL180M4 mutant, rtQ215S1 coexisting mutants | 1 (1.27) | |
rtA181T12 + rtV214A1 coexisting mutants | 1 (1.27) | |
rtA181T12 + rtN236T1 coexisting mutants | 2 (2.53) | |
rtA181T1 mutant, rtN236T1 coexisting mutants | 1 (1.27) | |
rtM204V45 + rtA181T12 coexisting mutants | 1 (1.27) | |
rtM204V45 mutant, rtA181T12 coexisting mutants | 1 (1.27) | |
rtM204V45 + rtV207M/L/I4 + rtQ215S1 mutant | 1 (1.27) | |
rtM204V45 + rtV214A1 mutant | 1 (1.27) | |
rtM204V45 mutant, rtA181T12 + rtQ215S1 coexisting mutants | 1 (1.27) | |
rtM204V45 mutant, rtN238T1 coexisting mutants | 1 (1.27) | |
rtV207M/L/I4 + rtA181T12 + rtV214A1 + rtN236T1 + rtM250L6 coexisting mutants | 1 (1.27) | |
rtV207M/L/I4 + rtA181T12 + rtN236T1 coexisting mutants | 1 (1.27) | |
rtV207M/L/I4 + rtV214A1 coexisting mutants | 1 (1.27) | |
rtV207M/L/I4 + rtA181T12 + rtN236T1 coexisting mutants | 1 (1.27) | |
rtS213T4 + rtA181T12 coexisting mutants | 1 (1.27) | |
rtS213T4 + rtN236T1 + rtM250L6 mutant | 1 (1.27) | |
rtN236T1 + rtN238T1 coexisting mutants | 1 (1.27) |
Table 2 Clinical features of rtA181T mutant and non-mutant rtA181T groups n (%)
Clinical features | rtA181T(n = 56) | Not rtA181T(n = 23) | Statistical value | P-value |
Gender (M/F) | 48/8 | 18/5 | χ2 = 0.659 | 0.507 |
Age (yr, mean ± SD) | 43.1 ± 9.3 | 43.4 ± 11.6 | t = 0.132 | 0.896 |
End-stage liver disease1 | 21 (37.5) | 11 (47.83) | χ2 = 0.721 | 0.396 |
NAFLD | 21 (37.5) | 9 (39.13) | χ2 = 0.018 | 0.892 |
E-antigen (+/–) | 27/29 | 18/5a | χ2 = 6.004 | 0.023 |
Genotype (B/C) | 7/49 | 9/14b | χ2 = 7.159 | 0.007 |
HBV DNA (log10 copy/mL) | 5.16 ± 1.23 | 5.14 ± 1.25 | t = 0.086 | 0.932 |
Duration of treatment (mo, mean ± SD) | 41.2 ± 10.1 | 40.8 ± 9.7 | t = 0.162 | 0.872 |
Table 3 Clinical features of single mutant and multi-mutant groups n (%)
Clinical features | Single mutant(n = 53) | Multi-mutants(n = 26) | Statistical value | P-value |
Gender (M/F) | 45/8 | 21/5 | χ2 = 0.217 | 0.749 |
Age (yr, mean ± SD) | 42.6 ± 10.5 | 44.5 ± 8.9 | t = 0.806 | 0.423 |
End-stage liver disease1 | 21 (39.62) | 11 (42.31) | χ2 = 0.721 | 0.396 |
NAFLD | 19 (35.85) | 11 (42.31) | χ2 = 0.137 | 0.712 |
E-antigen (+/–) | 24/29 | 12/14 | χ2 = 0.005 | 1.000 |
Genotype (B/C) | 10/43 | 6/20 | χ2 = 0.022 | 0.883 |
HBV-DNA (log10 copy/mL) | 5.06 ± 1.24 | 5.35 ± 1.21 | t = 0.989 | 0.326 |
Duration of treatment (mo, mean ± SD) | 38.6 ± 8.2 | 43.9 ± 10.8a | t = 2.426 | 0.018 |
Table 4 Clinical features of the rtA181T mutant and rN236T groups n (%)
Clinical features | rtA181T mutant(n = 50) | rtN236T mutant(n = 7) | Statistical value | P-value |
Gender (M/F) | 43/7 | 7/0 | χ2 = 0.069 | 0.792 |
Age (yr, mean ± SD) | 42.6 ± 9.4 | 47.3 ± 12.1 | t = 1.201 | 0.235 |
End-stage liver disease1 | 19 (38) | 3 (42.86) | χ2 = 0.026 | 1.000 |
NAFLD | 20 (40) | 3 (42.86) | χ2 = 0.009 | 1.000 |
E-antigen (+/–) | 25/25 | 2/5 | χ2 = 1.131 | 0.427 |
Genotype (B/C) | 7/43 | 5/2a | χ2 = 5.958 | 0.028 |
HBV-DNA (log10 copy/mL) | 5.18 ± 1.23 | 4.91 ± 1.20 | t = 0.544 | 0.588 |
- Citation: Jiang SW, Yao LP, Hu AR, Hu YR, Chen SX, Xiong T, Gao GS, Liang XY, Ding SX, Weng PJ. Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates. World J Gastroenterol 2014; 20(45): 17100-17106
- URL: https://www.wjgnet.com/1007-9327/full/v20/i45/17100.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i45.17100