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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 28, 2014; 20(44): 16452-16463
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16452
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16452
Host protein/factor | Function |
Fiaf (fasting-induced adipocyte factor) | A protein that inhibits lipoprotein lipase activity |
ChREBP (carbohydrate response element-binding protein) | A transcription factor that recognizes monosaccharides in the portal vein and plays a key role in the hepatic carbohydrate metabolism |
SREBP-1 (liver sterol response element-binding protein type-1) | A transcription factor family that controls the lipid synthesis in the liver and other tissues |
G-protein coupled receptors (GPR43 and GPR41) | Proteins expressed in enteroendocrine L-cells those recognize luminal SCFAs and mediate SCFA-induced GLP-1 release. They also present in adipocytes and promote adipogenesis by increasing lipid accumulation and inhibiting lipolysis and stimulate leptin production in response to SCFAs |
Toll like receptors | Transmembrane molecules those recognize bacterial breakdown products |
GLP 1 (Glucagon-like peptide 1) | A protein produced by intestinal epithelial endocrine L-cells that stimulates insulin secretion, inhibits gastrointestinal motility, regulates appetite and food intake |
Peptide YY | A peptide hormone produced by intestinal epithelial endocrine L-cells that inhibits intestinal motility |
Farnesoid X receptor | A receptor expressed in liver and intestine that regulates bile acid synthesis,transport and detoxification |
- Citation: Arslan N. Obesity, fatty liver disease and intestinal microbiota. World J Gastroenterol 2014; 20(44): 16452-16463
- URL: https://www.wjgnet.com/1007-9327/full/v20/i44/16452.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i44.16452