Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection

Table 1 Overall antibiotic resistance of 132 isolated Helicobacter pylori strains isolated from 66 patients n (%)

Antibiotic	Patients with resistantHelicobacter pylori strains	95%CI
Amoxicillin	0 (0)
Clarithromycin	29 (43.9)	0.32-0.56
Metronidazole	34 (51.5)	0.39-0.64
Tetracycline	0 (0)
Levofloxacin	15 (22.7)	0.09-0.28
Rifabutin	3 (4.5)	0.01-0.04

Table 2 Antibiotic resistance of Helicobacter pylori strains depending on the number of eradication therapies n (%)

	Patients with resistant Helicobacter pylori strains	95%CI
No previous eradication therapy (n = 29)
Clarithromycin	2 (6.9)	0.03-0.18
Metronidazole	5 (17.2)	0.03-0.34
Levofloxacin	4 (13.8)	0.02-0.24
One previous eradication therapy (n = 13)
Clarithromycin	7 (53.8)	0.30-0.98
Metronidazole	9 (69.2)	0.30-0.98
Levofloxacin	3 (23.1)	0.04-0.59
Two or more previous eradication therapies (n = 24)
Clarithromycin	20 (83.3)	0.63-0.97
Metronidazole	20 (83.3)	0.69-0.99
Levofloxacin	8 (33.3)	0.09-0.47
Rifabutin	3 (12.5)	0.04-0.12

Table 3 Antibiotic susceptibility in patients with discordant resistance pattern between antrum and corpus biopsies

Patients	Clarithromycin	Metronidazole	Levofloxacin	Rifabutin
Patient 1
Antrum	Resistant	Resistant	Susceptible	Susceptible
Corpus	Susceptible	Resistant	Resistant	Susceptible
Patient 2
Antrum	Susceptible	Resistant	Susceptible	Susceptible
Corpus	Susceptible	Resistant	Resistant	Susceptible
Patient 3
Antrum	Resistant	Resistant	Susceptible	Susceptible
Corpus	Susceptible	Susceptible	Susceptible	Susceptible
Patient 4
Antrum	Resistant	Resistant	Susceptible	Susceptible
Corpus	Resistant	Resistant	Resistant	Resistant
Patient 5
Antrum	Susceptible	Resistant	Susceptible	Susceptible
Corpus	Susceptible	Susceptible	Susceptible	Susceptible
Patient 6
Antrum	Resistant	Resistant	Susceptible	Susceptible
Corpus	Resistant	Susceptible	Susceptible	Susceptible
Patient 7
Antrum	Susceptible	Susceptible	Resistant	Susceptible
Corpus	Susceptible	Susceptible	Susceptible	Susceptible
Patient 8
Antrum	Resistant	Resistant	Resistant	Susceptible
Corpus	Resistant	Resistant	Resistant	Resistant
Patient 9
Antrum	Resistant	Susceptible	Resistant	Susceptible
Corpus	Resistant	Susceptible	Susceptible	Susceptible
Patient 10
Antrum	Resistant	Resistant	Susceptible	Susceptible
Corpus	Resistant	Susceptible	Susceptible	Susceptible