Copyright
©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2014; 20(43): 16227-16235
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16227
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16227
Table 1 Primary pairs for real-time polymerase chain reaction of genes related to hepatic fatty acid metabolism
Gene name | Accession | Forward | Reverse |
PPARα | Mm00440939 | ||
SREBP-1c | Mm00550338 | ||
SCD-1 | GTTGGCTCCATCCATTGC | AACCATGGGAAGCCAAGTTT | |
FAS | AACCTCAGCAACACATCT | CGTTTACAAAGGGCATGCA | |
MTP | Mm00435015 | ||
CPT1 | CCCTGGGCATGATTGCAA | AAGAGGACGCCACTCACGAT |
Table 2 Metabolic laboratory findings from each experimental mice group
Laboratory findings | Lean | ob/ob | ob/ob + MK-0626 (1.5 mg/kg) | ob/ob + MK-0626 (3 mg/kg) |
Glucose (mg/dL) | 141 ± 43.8 | 349 ± 15.7 | 288 ± 17.6a | 247 ± 42.5b |
Insulin (μU/mL) | 1.83 ± 0.61 | 11.54 ± 0.59 | 8.42 ± 1.03a | 7.83 ± 0.44b |
HOMA score | 0.63 ± 0.06 | 9.96 ± 2.32 | 5.98 ± 0.52a | 4.78 ± 0.166b |
ALT (U/L) | 43.3 ± 10.3 | 590 ± 109.5 | 278 ± 70.5a | 272.5 ± 131.5a |
Adiponectin (μg/mL) | 31.15 ± 2.07 | 34.57 ± 1.25 | 37.86 ± 3.40 | 39.90 ± 1.28a |
-
Citation: Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M. MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in
ob/ob mice. World J Gastroenterol 2014; 20(43): 16227-16235 - URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16227.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16227