Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics

Table 1 Baseline clinicopathologic characteristics of gastric epithelial dysplasias according to the morphologic type n (%)

	Morphologic type			P value
	Adenomatous	Hybrid	Foveolar
	(n = 27)	(n = 15)	(n = 4)
Age (yr, mean ± SD)	59.4 ± 7.3	67.1 ± 9.0	64.3 ± 7.5	0.023
Sex				0.413
Male	16 (59)	9 (60)	4 (100)
Female	11 (41)	6 (40)	0 (0)
Tumor size (cm, mean ± SD)	1.3 ± 0.5	1.7 ± 1.1	1.9 ± 1.1	0.242
Location				0.251
Body/fundus	17 (63)	6 (40)	1 (25)
Antrum	10 (37)	9 (60)	3 (75)
Color				0.172
Discolored	13 (48)	3 (20)	1 (25)
Norma/reddish	14 (52)	12 (80)	3 (75)
Gross shape				0.328
Elevated/protruded	24 (89)	11 (73)	3 (75)
Flat/depressed	3 (11)	4 (27)	1 (25)
Histologic grade				0.328
Low	24 (89)	11 (73)	3 (75)
High	3 (11)	4 (27)	1 (25)
H. pylori infection				0.020
Present	23 (85)	7 (47)	2 (50)
Absent	4 (15)	8 (53)	2 (50)
Mucin phenotype				< 0.001
G-type	1 (4)	8 (53)	4 (100)
I-type	22 (82)	0 (0)	0 (0)
GI-type	2 (7)	6 (40)	0 (0)
N-type	2 (7)	1 (7)	0 (0)

H. pylori: Helicobacter pylori; G-type: Gastric-type; I-type: Intestinal-type; GI-type: Gastrointestinal-type; N-type: Unclassified-type.

Table 2 Magnifying endoscopy using narrow band imaging of gastric epithelial dysplasias according to the morphologic type n (%)

	Morphologic type			P value
	Adenomatous	Hybrid	Foveolar
	(n = 27)	(n = 15)	(n = 4)
Microsurface pattern				< 0.001
Round pit	2 (7)	1 (7)	0 (0)
Tubular	15 (56)	2 (13)	0 (0)
Mixed	10 (37)	5 (33)	0 (0)
Papillary	0 (0)	5 (33)	4 (100)
Absent	0 (0)	2 (13)	0 (0)
Microvascular pattern				0.517
Regular	12 (44)	4 (27)	1 (25)
Irregular	15 (56)	11 (73)	3 (75)
Light blue crest				0.127
Present	14 (52)	5 (33)	0 (0)
Absent	13 (48)	10 (67)	4 (100)
White opaque substance				1
Present	9 (33)	5 (33)	1 (25)
Absent	18 (67)	10 (67)	3 (75)

Table 3 Mcrosurface and microvascular patterns according to mucin expression in gastric epithelial dysplasias n (%)

	Microsurface pattern			P value	Microvasulcar pattern		P value
	Round pit and/or tubular	Papillary	Absent		Regular	Irregular
	(n = 35)	(n = 9)	(n = 2)		(n = 17)	(n = 29)
MUC2 expression				0.569			0.545
Negative (< 10%)	33 (94)	8 (89)	2 (100)		15 (88)	28 (97)
Positive (≥ 10%)	2 (6)	1 (11)	0 (0)		2 (12)	1 (3)
MUC5AC expression				0.001			0.301
Negative (< 10%)	26 (74)	1 (11)	1 (50)		12 (71)	16 (55)
Positive (≥ 10%)	9 (26)	8 (89)	1 (50)		5 (29)	13 (45)
MUC6 expression				0.014			0.149
Negative (< 10%)	28 (80)	3 (33)	1 (50)		14 (82)	18 (62)
Positive (≥ 10%)	7 (20)	6 (67)	1 (50)		3 (18)	11 (38)
CD10 expression				< 0.001			0.417
Negative (< 10%)	7 (20)	8 (89)	2 (100)		5 (29)	12 (41)
Positive (≥ 10%)	28 (80)	1 (11)	0 (0)		12 (71)	17 (59)

Table 4 Presence or absence of light blue crest and white opaque substance according to mucin expression in gastric epithelial dysplasias n (%)

	Light blue crest		P value	White opaque substance		P value
	Absent (n = 27)	Present (n = 19)		Absent (n = 31)	Present (n = 15)
MUC2 expression			1			1
Negative (< 10%)	25 (93)	18 (95)		29 (94)	14 (93)
Positive (≥ 10%)	2 (7)	1 (5)		2 (6)	1 (7)
MUC5AC expression			0.220			0.575
Negative (< 10%)	14 (52)	14 (74)		18 (58)	10 (67)
Positive (≥ 10%)	13 (48)	5 (26)		13 (42)	5 (33)
MUC6 expression			0.106			0.495
Negative (< 10%)	16 (59)	16 (84)		23 (74)	9 (60)
Positive (≥ 10%)	11 (41)	3 (16)		8 (26)	6 (40)
CD10 expression			0.002			0.723
Negative (< 10%)	15 (56)	2 (11)		12 (39)	5 (33)
Positive (≥ 10%)	12 (44)	17 (89)		19 (61)	10 (67)