Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients

Table 1 Clinical features and their association with the occurrence of infection n (%)

	Infection		Total	P value
	No	Yes
Gender
F	26 (54)	23 (40)	49 (46.23)	0.1358
M	22 (46)	35 (60)	57 (53.77)
Age
< 65	36 (80)	37 (65)	73 (71.57)	0.0935
≥ 65	9 (20)	20 (35)	29 (28.43)
Stage
I	2 (4)	7 (12)	9 (8.65)	0.2875
II	12 (25)	12 (21)	24 (23.00)
III	24 (50)	21 (38)	45 (44.11)
IV	10 (21)	16 (29)	26 (24.24)
Treatment
Adjuvant	27 (69)	24 (48)	51 (48.11)	0.0528
Adjuvant + neoadjuvant	9 (23)	13 (26)	22 (20.75)
Surgery	3 (8)	13 (26)	16 (15.10)
Others	-	-	17 (16.04)
Metastasis
Não	32 (71)	44 (76)	76 (73.78)	0.5866
Sim	13 (29)	14 (24)	27 (26.22)
T stage
1 + 2	6 (14)	11 (20)	17(17.70)	0.4385
3 + 4	36 (86)	43 (80)	79 (82.30)
Lymph node involvement
0	17 (41)	21 (38)	38 (39.17)	0.6928
1 + 2	24 (59)	35 (62)	59 (60.83)

In some cases the total number did not reach 106 because the data was not available on medical records.

Table 2 Etiological agents of bacterial infections

Bacteria (etiological agents)	Classification	Diagnosis of Colorectal Cancer
Staphylococcus aureus (S. aureus)	Gram-positive	15
Escherichia coli	Gram-negative	11
Pseudomonas aeruginosa (P. aeruginosa)	Gram-negative	10
Staphylococcus epidermidis	Gram-positive	6
Enterobacter cloacae	Gram-negative	7
Klebsiella pneumoniae	Gram-negative	6
Serratia marcescens	Gram-negative	1
Enterobacter aerogenes	Gram-negative	4
Proteus mirabilis	Gram-negative	1
Acinetobacter baumannii	Gram-negative	3
Coagulase negative Staphylococcus	Gram-negative	3
Enterococcus faecalis	Gram-positive	1
E. faecium	Gram-positive	2
Citrobacter freundii	Gram-negative	2
Enterobacter cloacae + P. aeruginosa	Gram-negative	1
Staphylococcus lugdunensis	Gram-positive	2
Klebsiella pneumoniae +	Gram-negative	1
Escherichia coli
S. aureus + Klebsiela	Gram-positive and	1
	Gram-negative
Pseudomonas aeruginosa + S. aureus	Gram-positive and	1
	Gram-negative
Citrobacter amalonaticus	Gram-negative	1
Enterococcus avium	Gram-positive	1
Serratia odorifera	Gram-negative	1
Klebsiella pneumoniae + Pseudomonas aeruginosa	Gram-negative	1
P. aeruginosa + Klebsiella pneumoniae	Gram-negative	1
Staphylococcus saprophyticus	Gram-positive	1
Staphylococcus sp	Gram-positive	1
Streptococcus viridans	Gram-positive	1
	Total	86

Table 3 Multivariate analysis for cancer-specific survival in colorectal cancer

Variabel	Category	HR	95%CI	P value
Infecion	no	1	-
	yes	2.62	1.26-5.45	0.01
Stage	I + II	1	-
	III + IV	2.63	1.08-6.39	0.03

Variables included in multivariate analysis were treatment, staging and infection. Multivariate analysis employed Cox test assuming a proportional hazards model.