MicroRNAs: Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential

doi:10.3748/wjg.v20.i38.13658

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 38

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (8367)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

562

WORD

302

HTML

4201

Figures (1-1)

279

Tables (1-2)

239

Sum=5583

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1394

Download

1390

Sum=2784

Oct 14, 2014 (publication date) through Dec 22, 2024

Times Cited of This Article

Times Cited (22)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Topic Highlight

World J Gastroenterol. Oct 14, 2014; 20(38): 13658-13666
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13658

Table 1 MicroRNAs as potential diagnostic biomarkers for chemoresistance in gastric cancer

miRNAs	Regulation	Drug resistance cell lines	Target	Ref.
miR-15b	Down ↓	Vincristine	PTEN	[62]
miR-16	Down ↓	Vincristine	PTEN	[62]
miR-19a/b	Up ↑	Doxorubicin, vincristine	PTEN	[77]
miR-21	Up ↑	Cisplatin	PTEN	[78]
miR-106a	Up ↑	Cisplatin	PTEN	[79]
miR-181b	Down ↓	Cisplatin, vincristine	BCL-2	[82]
miR-497	Down ↓	Cisplatin, vincristine	BCL-2	[83]
miR-200b/c	Down ↓	Cisplatin, vincristine	BCL-2, XIAP	[83]
miR-508-5p	Down ↓	Vincristine, doxorubicin	ABCB1, ZNRD1	[81]

The table presents an overview about miRNAs that present different expression pattern between chemotherapy resistant gastric cancer cell lines and controls, including downstream targets and affected chemotherapeutic agents. PTEN: Phosphatase and Tensin homolog; BCL-2: B-cell lymphoma 2; XIAP: X-linked inhibitor of apoptosis protein; ABCB1: ATP-binding cassette sub-family B member 1; ZNRD1: DNA-directed RNA polymerase I subunit RPA12; miRNA: MicroRNA.

Table 2 MicroRNAs as potential therapeutic biomarkers for chemoresistance in gastric cancer

miRNAs	Regulation	Drug resistance	Target in GC	Drug treatment	Ref.
miR-21	Up ↑	Up ↑	PTEN	Cisplatin	[78]
miR-27a	Down ↓	Down ↓	Cyclin-D1, p21	Vincristine, 5-fluouracil, cisplatin, doxorubicin	[87]
miR-106a	Up ↑	Up ↑	PTEN	Cisplatin	[79]
miR-195	Up ↑	Up ↑	CDK6, VEGF	5-azacytidine	[80]
miR-378	Up ↑	Up ↑	CDK6, VEGF	5-azacytidine	[80]
miR-449a	Up ↑	Down ↓	BCL-2, CCDN1	Cisplatin	[88]
miR-508-5p	Up ↑	Down ↓	ABCB1, ZNRD1	Vincristine, doxorubicin	[81]

The table presents an overview about miRNAs that impact on chemotherapy resistance in gastric cancer cell lines, including downstream targets and affected chemotherapeutic agents. PTEN: Phosphatase and Tensin homolog; CDK6: Cylin-dependent kinase 6; VEGF: Vascular endothelial growth factor; BCL-2: B-cell lymphoma 2; CCDN1: Cyclin-D1 gene; ABCB1: ATP-binding cassette sub-family B member 1; ZNRD1: DNA-directed RNA polymerase I subunit RPA12; MiRNA: MicroRNA.

Citation: Matuszcak C, Haier J, Hummel R, Lindner K. MicroRNAs: Promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential. World J Gastroenterol 2014; 20(38): 13658-13666
URL: https://www.wjgnet.com/1007-9327/full/v20/i38/13658.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i38.13658