Laparoscopic distal pancreatectomy for adenocarcinoma of the pancreas

Table 1 Series on laparoscopic distal pancreatectomy that include adenocarcinoma of the pancreas and oncological outcome n (%)

Ref.	Number		Lymph nodes	R0	Tumor size (mm)
	Total	AC
Song et al[47]	359	34 (9)	10.31	92%	30 (26)1
Fernández-Cruz et al[38]	82	18 (22)	14.52	90%2	53
Marangos et al[48]	30	28 (93)	5	93%	50
Taylor et al[43]	46	10 (22)	-	100%3	-
Melotti et al[39]	58	7 (12)	13	100%	354
Asbun et al[49]	29	5 (17)	14 (19)1	97%	-
Edwin et al[32]	17	4 (24)	-	88 (50)1	28
Dulucq et al[34]	21	3 (14)	18	100%	42
Bärlehner et al[27]	5	2 (40)	19/6	R0/Rx	-
Sa Cunha et al[46]	31	1 (3)	-	100%5	37
D‘Angelica et al[35]	16	1 (6)	5.5	77%	40

¹Indicates numbers from adenocarcinoma diagnosis only;

²Indicates numbers from ductal adenocarcinoma only (n = 13); the other 5 had R0 resection;

³In 7 malignant cases completed with laparoscopic distal pancreatectomy, all having R0 resection;

⁴Indicates numbers from ductal adenocarcinoma only, for 2 mucinous cystadenocarcinoma the corresponding number is 38 mm;

⁵One ductal adenocarcinoma with R0 margins. AC: Adenocarcinoma of the pancreas.

Table 2 Series on laparoscopic distal pancreatectomy that include adenocarcinoma of the pancreas but not oncological outcome n (%)

Ref.	Number		Comment
	Total	AC
Weber et al[50]	219	16 (7)
Mabrut et al[33]	127	6 (5)
Giulianotti et al[51]	46	8 (17)	Robot-assisted LDP
Butturini et al[52]	43	1 (2)
Laxa et al[45]	32	3 (9)	7 hand-assisted
Corcione et al[37]	13	3 (16)
Patterson et al[25]	15	2 (13)
Lebedyev et al[31]	12	4 (33)
Gagner et al[14]	8	1 (13)
Santoro et al[21]	2	1 (50)

AC: Adenocarcinoma of the pancreas; LDP: Laparoscopic distal pancreatectomy.

Table 3 Studies comparing laparoscopic distal pancreatectomy and open distal pancreatectomy that include adenocarcinoma of the pancreas and oncological outcomes n (%)

Ref.	Number		Number AC		Lymph nodes		Tumor size (mm)		R0
	LDP	ODP	LDP	ODP	LDP	ODP	LDP	ODP	LDP	ODP
Jayaraman et al[68]	107	236	17 (16)	47 (20)	6	7 NS	30	30	97%	96%
Vijan et al[66]	100	100	17 (17)	19 (19)	NS	NS	33	40	100%	100%
Stauffer et al[75]	82	90	18 (22)	21 (23)	16.5	11 NS	20	28	97%	94%
DiNorcia et al[67]	71	168	3 (4)	51 (30)	6	8 NS	25	36	97%	87%
Abu Hilal et al[54]	35	16	4 (11)	3 (19)	-	-	34	33	75%	67%
Mehta et al[72]	30	30	7 (23)	7 (23)	8.4	13.8 NS	38	43	-	-
Baker et al[64]	27	85	1 (4)	18 (21)	5.2	9.4a	38	40	-	-
Magge et al[63]	28	34	28 (100)	34 (100)	11	12 NS	37	45	86%	88%
Kooby et al[61]	23	189	23 (100)	189 (100)	13.8	12.5 NS	35	45	74%	73%
Waters et al[71]	18	22	2 (11)	11 (50)	11	14 NS	40	60	100%	82%
Limongelli et al[56]	16	29	1 (6)	7 (24)	-	-	32	43	94%	93%
Rehman et al[76]	8	14	8 (100)	14 (100)	16	14	22	32	88%	86%
Kang et al[69]	5	27	5 (100)	27 (100)	8.2	11.3 NS	24	42	100%	85%

^aP < 0.05 vs laparoscopic distal pancreatectomy (LDP) group. ODP: Open distal pancreatectomy; NS: Not significant; AC: Adenocarcinoma of the pancreas.

Table 4 Studies comparing laparoscopic distal pancreatectomy and open distal pancreatectomy that include adenocarcinoma of the pancreas but not oncological outcomes n (%)

Ref.	Number		Number AC		Tumor size
	LDP	ODP	LDP	ODP	LDP	ODP
Finan et al[65]	44	98	6 (13.6)	23 (22.1)	33	77
Fox et al[55]	42	76	2 (5)	2 (3)	29	35
Casadei et al[70]	22	22	2 (9)1	2 (9)1	20	50
Velanovich et al[36]	15	41	3 (20)	13 (32)	-	-

¹Malignant cystic tumors that may represent cystadenocarcinoma. ODP: Open distal pancreatectomy; LDP: Laparoscopic distal pancreatectomy.

Table 5 Studies presenting survival data after laparoscopic distal pancreatectomy for pancreatic adenocarcinoma and include at least 5 cases

Ref.	Year	n	Survival
Song et al[47]	2011	34	2 year 85%
Marangos et al[48]	2012	28	3 year 30%
Magge et al[63]	2013	28	Median 19 mo
Kooby et al[61]	2010	23	Median 16 mo
Fernández-Cruz et al[38]	2007	22	Median 14 mo
Rehman et al[76]	2013	8	3 year 82%
Giulianotti et al[51]	2010	8	Median 15 mo (2 lost in follow up)
Melotti et al[39]	2007	7	85% alive after median follow up 26 mo
Kang et al[69]	2010	5	Median 28 mo