Metachronous gastric cancer after successful Helicobacter pylori eradication

Table 1 Incidence of metachronous cancer after successful Helicobacter pylori eradication

Ref.	Country	Subject No.	Study design	Mean follow-up periods	Incidence (%)	Eradication effect(95%CI)
Uemura et al[62], 1997	Japan	65/67	NR	3 yr	0 vs 9	effective P = 0.011
Fukase et al[14], 2008	Japan	272/272	Multicenter open-label RCT	3 yr	3.3 vs 8.8	effective 0.35 (0.16-0.78) P = 0.009
Shiotani et al[12], 2008	Japan	80	single arm	33 mo	11.3
Hanaoka et al[66], 2010	Japan	82		55 mo	14.6
Maehata et al[63], 2012	Japan	177/91	retro NR	3 yr 1.1-11.1 yr	8.5 vs 14.3	OR = 1.71 (0.72-4.03)
Kato et al[64], 2013	Japan	263/105	Multicenter retro cohort	26.8 mo 2-5 yr	3.5/Y	NS
Seo et al[65], 2013	South Korea	61/13	retro cohort	27.2 mo	9.8 vs 23.1	OR = 0.36 (0.08-1.70),
Chon et al[69], 2013	South Korea	129 85/44	Retro NR	26 mo 16.5-30 mo	4.7 vs 11.4	effective HR = 0.143 P = 0.008

Subject No.: Number of subjects with eradication/without eradication and with failure of eradication; RCT: Randomized controlled trial; NR: Non-randomized; Retro: retrospective; NS: Not significant.