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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 14, 2014; 20(30): 10518-10524
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10518
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10518
Table 1 Demographics and clinicopathologic characteristics n (%)
EGC | AGC | |
(n = 1001) | (n = 787) | |
Sex (male:female) | 668:333 | 520:267 |
Age (yr) | 59.0 ± 11.5 | 59.4 ± 12.5 |
Tumor size (cm) | 2.9 ± 1.8 | 5.8 ± 3.1 |
Borrmann type (%) | - | I: 3.3 |
II: 16.5 | ||
III: 64.7 | ||
IV: 10.2 | ||
V: 1.4 | ||
WHO classification (%) | Differentiated: 58.8 | Differentiated: 37.6 |
Undifferentiated: 40.2 | Undifferentiated: 62.0 | |
Lauren classification (%) | Intestinal: 57.3 | Intestinal: 36.5 |
Diffuse: 34.9 | Diffuse: 55.3 | |
Operation method (DG:TG) | 915:86 | 539:248 |
Lymphatic invasion (%) | 14.6 | 68 |
Vascular invasion (%) | 1.2 | 20.5 |
Perineural invasion (%) | 2.4 | 62.8 |
Harvested lymph nodes | 40.2 ± 15.0 | 49.6 ± 19.5 |
Positive lymph nodes | 0.4 ± 2.4 | 6.7 ± 9.6 |
Proximal resection margin (cm) | 3.6 ± 2.4 (0.1-16.5) | 3.3 ± 2.6 (0.1-13.5) |
Distal resection margin (cm) | 5.7 ± 3.8 (0.1-25.5) | 5.6 ± 4.7 (0.1-26.2) |
Stage (%) | I: 96.1 | I: 14.1 |
II: 3.9 | II: 31.8 | |
III: 0.0 | III: 48.5 | |
IV: 0.0 | IV: 5.6 | |
Recurrence | 19 (1.9) | 233 (29.6) |
Local recurrence | 6 (0.6) | 29 (3.7) |
Table 2 Overall appearance of adjusted hazard ratio
Tumor type | Cut-off value | HR (95%CI, P value) - OS | HR (95%CI, P value) - RFS |
EGC | PM = 0.5 cm | 0.300 (0.074-1.218, 0.092) | 0.310 (0.050-1.927, 0.209) |
EGC | PM = 1 cm | 0.541 (0.158-1.850, 0.327) | 0.494 (0.112-2.177, 0.351) |
EGC | PM = 2 cm | 1.208 (0.433-3.366, 0.718) | 1.367 (0.379-4.928, 0.632) |
EGC | DM = 1 cm | 9.229 (0.479-177.727, 0.141) | 12.979 (0.174-969.978, 0.244) |
EGC | DM = 2 cm | 2.350 (0.520-10.620, 0.267) | 2.354 (0.444-12.476, 0.314) |
AGC | PM = 0.5 cm | 1.122 (0.658-1.915, 0.672) | 0.870 (0.535-1.417, 0.577) |
AGC | PM = 1 cm | 0.922 (0.608-1.398, 0.703) | 0.917 (0.623-1.351, 0.661) |
AGC | PM = 2 cm | 0.979 (0.674-1.422, 0.911) | 1.050 (0.738-1.495, 0.786) |
AGC | DM = 0.5 cm | 0.615 (0.366-1.032, 0.066) | 0.772 (0.458-1.302, 0.332) |
AGC | DM = 1 cm | 0.706 (0.466-1.070, 0.101) | 0.852 (0.570-1.273, 0.434) |
AGC | DM = 2 cm | 1.109 (0.787-1.563, 0.554) | 1.338 (0.952-1.882, 0.093) |
Table 3 Survival-related factors in early gastric cancer
Clinicopathologic factors | Univariable analysis for OS (P value, HR) | Multivariable analysis for OS (P value, HR) | Univariable analysis for RFS (P value, HR) | Multivariable analysis for RFS (P value, HR) |
Sex | 0.094, 0.438 | 0.117, 0.373 | ||
Age | < 0.001, 1.086 | < 0.001, 1.081 | 0.848, 1.004 | |
Size of the tumor | 0.003, 1.267 | 0.124, 1.158 | 0.018, 1.253 | 0.515, 1.079 |
Operation method | 0.270, 1.185 | 0.618, 0.599 | ||
Lymphatic invasion | < 0.001, 5.289 | 0.077, 2.437 | < 0.001, 13.310 | < 0.001, 7.689 |
Vascular invasion | 0.219, 3.503 | 0.002, 10.119 | 0.046, 0.208 | |
Perineural invasion | 0.005, 5.642 | 0.173, 2.416 | 0.027, 5.229 | 0.492, 0.580 |
WHO classification | 0.760, 0.886 | 0.441, 0.683 | ||
Lauren classification | 0.593, 0.783 | 0.601, 0.754 | ||
Harvested lymph node | 0.676, 0.994 | 0.658, 1.007 | ||
Positive lymph node | < 0.001, 1.065 | 0.164, 1.038 | < 0.001, 1.078 | 0.006, 1.068 |
PM | 0.405, 0.930 | 0.592, 1.049 | ||
DM | 0.609, 1.025 | 0.235, 0.916 | ||
Stage | < 0.001, 10.515 | 0.028, 3.836 | < 0.001, 16.028 | 0.168, 2.416 |
Table 4 Correlation between clinicopathologic factors and local recurrence
Clinicopathologic Factors | Univariable analysis for EGC (P value, HR) | Multivariable analysis for EGC (P value, HR) | Univariable analysis for AGC (P value, HR ) | Multivariable analysis for AGC (P value, HR) |
Sex | 0.403, 0.399 | 0.650, 1.194 | ||
Age | 0.946, 0.998 | 0.267, 0.984 | ||
Size of the tumor | 0.032, 1.385 | 0.097, 1.318 | < 0.001, 1.223 | 0.040, 1.146 |
Lymphatic invasion | 0.031, 5.895 | 0.078, 4.409 | 0.023, 4.052 | |
Vascular invasion | 0.999, 0.000 | 0.128, 1.879 | ||
Perineural invasion | 0.057, 8.357 | 0.013, 3.868 | 0.191, 2.327 | |
Borrmann Type | - | 0.007 | 0.167 | |
WHO Classification | 0.719, 0.731 | 0.059, 2.401 | ||
Lauren Classification | 0.602, 0.547 | 0.180, 1.825 | ||
Harvested lymph node | 0.696, 0.988 | 0.713, 1.003 | ||
Positive lymph node | 0.309, 1.055 | 0.012, 1.035 | 0.928, 1.002 | |
PM | 0.236, 0.745 | 0.579, 1.958 | ||
DM | 0.308, 0.862 | 0.769, 0.988 | ||
Stage | 0.998, 0.000 | 0.017 | 0.191 |
Table 5 Survival related factors in advanced gastric cancer
Clinicopathologic factors | Univariable analysis for OS (P value, HR) | Multivariable analysis for OS (P value, HR) | Univariable analysis for RFS (P value, HR) | Multivariable analysis for RFS (P value, HR) |
Sex | 0.449, 1.113 | 0.306, 1.150 | ||
Age | 0.025, 1.013 | 0.001, 1.020 | 0.470, 0.996 | |
Size of the tumor | < 0.001, 1.139 | 0.127, 1.046 | < 0.001, 1.177 | 0.012, 1.081 |
Operation method | 0.029, 1.361 | 0.145, 0.727 | 0.004, 1.474 | 0.091, 0.697 |
Lymphatic invasion | < 0.001, 3.537 | 0.696, 1.094 | < 0.001, 3.082 | 0.975, 0.993 |
Vascular invasion | < 0.001, 2.876 | 0.026, 1.428 | < 0.001, 2.868 | 0.094, 1.313 |
Perineural invasion | < 0.001, 2.440 | 0.343, 1.189 | < 0.001, 2.342 | 0.634, 1.092 |
Borrmann type | < 0.001 | 0.087 | < 0.001 | 0.05 |
WHO Classification | 0.025, 1.389 | 0.856, 1.030 | 0.003, 1.537 | 0.169, 1.745 |
Lauren Classification | 0.099, 1.281 | 0.004, 1.530 | 0.165, 0.572 | |
Harvested lymph node | 0.191, 1.004 | 0.288, 1.003 | ||
Positive lymph node | < 0.001, 1.048 | 0.001, 1.021 | < 0.001, 1.047 | < 0.001, 1.021 |
PM | 0.278, 0.970 | 0.207, 0.966 | ||
DM | 0.047, 0.969 | 0.660, 1.009 | 0.035, 0.968 | 0.670, 1.009 |
Stage | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
- Citation: Lee CM, Jee YS, Lee JH, Son SY, Ahn SH, Park DJ, Kim HH. Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer. World J Gastroenterol 2014; 20(30): 10518-10524
- URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10518.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10518