Original Article
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 21, 2014; 20(3): 755-773
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.755
Table 1 Clinicopathologic characteristics and immunohistochemical expressions in 76 patients with extrahepatic cholangiocarcinoma
Parametersn (%)
SexMale47 (61.8)
Female29 (38.2)
Agemean ± SD63.1 ± 9.3
Surgical resectionCBD segmental Resection32 (42.1)
Whipple or PPPD44 (57.9)
Tumor size≥ 2 cm48 (63.2)
< 2 cm28 (36.8)
American Joint Commission on Cancer stageIA10 (13.2)
IB18 (23.7)
IIA20 (26.3)
IIB26 (34.2)
III1 (1.3)
IV1 (1.3)
Histologic typeWell-differentiated19 (25.0)
Moderately-differentiated46 (60.5)
Poorly-differentiated11 (14.5)
Resection marginR057 (75.0)
R119 (25.0)
Angiolymphatic invasionAbsent31 (40.8)
Present45 (59.2)
Perineural invasionAbsent36 (47.4)
Present40 (52.6)
Regional lymph nodes involvementAbsent49 (64.5)
Present27 (35.5)
Skp2 immunostainingIntensity
032 (42.1)
121 (27.6)
216 (21.1)
37 (9.2)
Immunoreactive score
043 (56.6)
110 (13.2)
215 (19.7)
36 (7.9)
62 (2.6)
Cyclin-dependent kinases regulatory subunit 1 immunostainingIntensity
09 (11.8)
124 (31.6)
237 (48.7)
36 (7.9)
Immunoreactive score
024 (31.6)
112 (15.8)
226 (34.2)
31 (1.3)
48 (10.5)
64 (5.3)
91 (1.3)
p27kip1 immunostainingIntensity
023 (30.3)
131 (40.8)
215 (19.7)
37 (9.2)
Immunoreactive score
029 (38.2)
122 (28.9)
26 (7.9)
32 (2.6)
48 (10.5)
67 (9.2)
92 (2.6)
Ki-67 LImean ± SD4.0 ± 6.7
Table 2 Independent and significant prognostic factors for patients with extrahepatic cholangiocarcinoma
ParametersCategoryOR95%CIP value
Age> 65 yr2.7071.341-5.464< 0.01
AJCC stageIA
IB2.5430.695-9.3060.159
IIA0.8010.185-3.4770.767
IIB3.5341.041-11.9970.043
III16.4461.370-197.4700.027
IV92.9655.585-1547.531< 0.010
Histologic typeWell-differentiated
Moderately-differentiated6.0412.146-17.006< 0.010
Poorly-differentiated5.6201.586-19.917< 0.010
Immunostaining intensity of Skp20
11.3080.571-2.9940.526
23.7821.581-9.051< 0.010
32.3121.127-6.9410.048