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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 7, 2014; 20(29): 10151-10157
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10151
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10151
Table 1 Comparison of the two groups of patients according to patient and investigation characteristics (n = 665) n (%)
Patient and investigation characteristics | Indomethacin group(n = 347) | Control group(n = 318) |
Gender | ||
Male (n = 239) | 133 (55.64) | 106 (44.35) |
Female (n = 426) | 214 (50.23) | 212 (49.76) |
Age | ||
< 70 yr (n = 355) | 190 (53.52) | 165 (46.48) |
> 70 yr (n = 310) | 157 (50.65) | 153 (49.35) |
BMI | ||
< 25 (n = 303) | 156 (51.48) | 147 (48.51) |
25-30 (n = 236) | 125 (53.96) | 111 (47.03) |
> 30 (n = 126) | 66 (52.38) | 60 (47.62) |
Duration of ERCP | ||
< 20 min (n = 454) | 236 (52.0) | 218 (48.0) |
> 20 min (n = 211) | 111 (52.6) | 100 (47.4) |
Dilated/non-dilated bile duct | ||
Dilated (n = 366) | 189 (51.64) | 177 (48.36) |
Non-dilated (n = 299) | 158 (52.84) | 141 (47.15) |
Pancreatic duct opacification (n = 463) | 246 (53.13) | 217 (46.87) |
EST | ||
Biliary (n = 443) | 224 (50.56) | 219 (49.43) |
Pancreatic/double (n = 48) | 22 (44.0) | 28 (56.0) |
Difficult cannulation (n = 116) | 64 (55.17) | 52 (44.83) |
Gallstone extraction (n = 165) | 82 (49.7) | 83 (50.3) |
Bile duct dilatation (n = 22) | 11 (50.0) | 11 (50.0) |
Biliary stent placement | ||
Plastic stent (n = 75) | 35 (46.7) | 40 (53.3) |
Metal stent | 0 | 0 |
Table 2 Distribution of specific risk factors in the investigated population (n = 665) n (%)
Risk factors | Indomethacingroup (n = 347) | Control group(n = 318) | P value |
Age < 50 yr (n = 104) | 57/347 (16.4) | 47/318 (14.8) | 0.559 |
Female gender (n = 426) | 214/347 (61.7) | 212/318 (66.7) | 0.180 |
BMI > 25 (n = 362) | 191/347 (55.0) | 171/318 (53.8) | 0.743 |
Duration of ERCP > 20 min (n = 211) | 111/347 (32.0) | 100/318 (31.4) | 0.880 |
Non-dilated bile duct (n = 299) | 158/347 (45.5) | 141/318 (44.3) | 0.757 |
Pancreatic duct opacification (n = 463) | 246/347 (70.1) | 217/318 (68.2) | 0.534 |
EST biliary (n = 443) | 224/347 (64.6) | 219/318 (68.9) | 0.195 |
EST pancreatic/double (n = 48) | 20/347 (5.8) | 28/318 (8.8) | 0.130 |
Difficult cannulation (n = 116) | 64/347 (18.4) | 52/318 (16.4) | 0.111 |
Gallstone extraction (n = 165) | 82/347 (23.6) | 83/318 (26.1) | 0.461 |
Bile duct dilatation (n = 22) | 11/347 (3.2) | 11/318 (3.5) | 0.835 |
Biliary plastic stent placement (n = 75) | 35/347 (10.1) | 40/318 (12.6) | 0.640 |
Total (n = 2734) | 1413/4164 (33.9) | 1321/3816 (34.6) | 0.520 |
Table 3 Incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis and hyperamylasaemia (n = 665)
Group of patients | ERCP (n) | Pancreatitis (n) | Pancreatitis | Hyperamylasaemia (n) | Hyperamylasaemia |
Indomethacin | 347 | 20 (mild: 16, severe: 4) | 5.76% | 81 | 23.34% |
Control | 318 | 22 (mild: 18, severe: 4) | 6.92% | 79 | 24.84% |
Total | 665 | 42 | 6.32% | 160 | 24.06% |
Table 4 Incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis according to risk factors (n = 665) n (%)
Risk factors | Indomethacingroup | Control group | P value |
Age < 50 yr (n = 104) | 5/57 (8.77) | 6/47 (12.76) | 0.365 |
Female gender (n = 426) | 16/214 (7.47) | 19/212 (8.96) | 0.576 |
BMI > 25 (n = 362) | 12/191 (6.28) | 10/171 (5.85) | 0.862 |
Duration of ERCP > 20 min (n = 211) | 8/111 (7.2) | 7/100 (7.0) | 0.580 |
Non-dilated bile duct (n = 299) | 10/158 (6.33) | 11/141 (7.8) | 1.000 |
Pancreatic duct opacification (n = 463) | 20/246 (8.13) | 20/217 (9.21) | 0.263 |
EST biliary (n = 443) | 14/224 (6.25) | 14/219 (6.4) | 0.951 |
EST pancreatic/double (n = 48) | 4/20 (20.0) | 5/28 (17.86) | 0.560 |
Difficult cannulation (n = 116) | 4/64 (6.25) | 6/52 (11.54) | 0.478 |
Gallstone extraction (n = 165) | 3/82 (3.66) | 5/83 (6.02) | 0.451 |
Bile duct dilatation (n = 22) | 1/11 (9.1) | 2/11 (18.2) | 0.537 |
Biliary plastic stent placement (n = 75) | 4/35 (11.43) | 3/40 (7.5) | 0.580 |
- Citation: Döbrönte Z, Szepes Z, Izbéki F, Gervain J, Lakatos L, Pécsi G, Ihász M, Lakner L, Toldy E, Czakó L. Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis? World J Gastroenterol 2014; 20(29): 10151-10157
- URL: https://www.wjgnet.com/1007-9327/full/v20/i29/10151.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i29.10151