Association of metabolic syndromes and risk factors with ampullary tumors development: A case-control study in China

doi:10.3748/wjg.v20.i28.9541

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World Journal of Gastroenterology

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Case Control Study

World J Gastroenterol. Jul 28, 2014; 20(28): 9541-9548
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9541

Table 1 Risk factors for ampullary adenoma: univariate and multivariate logistic regression analyses using Fisher’s exact test n (%)

Risk factor	Controls	Cases	Univariate analysis		Multivariate analysis
Risk factor	Controls	Cases	P value	OR (95%CI)	P value	OR (95%CI)
Age
< 50 yr	45 (15.7)	8 (14.0)	1 (reference)
≥ 50 yr	240 (84.3)	49 (86.0)	0.843	1.148 (0.510-2.588)
Sex
Female	145 (50.9)	29 (50.9)	1 (reference)
Male	140 (49.1)	28 (49.1)	1.000	1.000 (0.566-1.766)
Smoking
No	225 (78.9)	44 (77.2)	1 (reference)
Yes	60 (21.1)	13 (22.8)	0.727	1.108 (0.561-2.189)
Alcohol abuse
No	209 (73.3)	48 (84.2)	1 (reference)
Yes	76 (26.7)	9 (15.8)	0.094	0.516 (0.241-1.101)
HBV
HBsAg-/anti-HBc-	147 (51.6)	32 (56.1)	1 (reference)
HBsAg+/anti-HBc+	7 (2.5)	_	_	_
HBsAg-/anti-HBc+	131 (45.9)	25 (43.9)	0.665	0.877 (0.494-1.556)
Diabetes mellitus					0.041	2.590 (1.055-6.676)
No	262 (91.9)	46 (80.7)	1 (reference)
Yes	23 (8.1)	11 (19.3)	0.015	2.274 (1.244-5.965)
Hypertension
No	219 (76.8)	35 (61.4)	1 (reference)
Yes	66 (23.2)	22 (38.6)	0.020	2.086 (1.145-3.801)
Cholecystolithiasis					0.000	11.068 (3.395-36.084)
No	273 (95.8)	41 (71.9)	1 (reference)
Yes	12 (4.2)	16 (28.1)	0.000	8.878 (3.921-20.103)
Cholecystectomy
No	278 (97.5)	46 (80.7)	1(reference)
Yes	7 (2.5)	11 (19.3)	0.000	9.497 (3.502-25.755)
Chronic pancreatitis
No	283 (99.3)	53 (93.0)	1(reference)
Yes	2 (0.7)	4 (7.0)	0.008	10.679 (1.907-59.79)
TC (mmol/L)
< 5.70	240 (84.2)	39 (68.4)	1 (reference)
≥ 5.70	45 (15.8)	18 (31.6)	0.008	2.462 (1.294-4.682)
Tri (mmol/L)
< 1.7	200 (70.2)	40 (70.2)	1 (reference)
≥ 1.7	85 (29.8)	17 (29.8)	1.000	1.000 (0.537-1.862)
HDL (mmol/L)
< 0.93	29 (10.2)	20 (35.1)	1 (reference)
≥ 0.93	256 (89.8)	37 (64.9)	0.000	0.210 (0.108-0.408)
LDL (mmol/L)					0.004	3.039 (1.412-6.541)
< 3.63	237 (83.2)	35 (61.4)	1 (reference)
≥ 3.63	48 (16.8)	22 (38.6)	0.001	3.104 (1.675-5.752)
FBG (mmol/L)
< 6.1	242 (84.9)	42 (73.7)	1 (reference)
≥ 6.10	43 (15.1)	15 (26.3)	0.052	2.010 (1.026-3.939)
ApoA (g/L)
< 1	2 (0.7)	20 (35.1)	1 (reference)		0.000	105.282 (22.229-498.635)
≥ 1	283 (99.3)	37 (64.9)	0.000	0.013 (0.003-0.058)
ApoB (g/L)
< 1	208 (72.9)	32 (56.1)	1 (reference)
≥ 1	77 (27.1)	25 (43.9)	0.017	2.110 (1.176-3.788)
BMI (kg/m²)
< 25.0	164 (57.5)	40 (70.2)	1 (reference)
≥ 25.0	121 (42.5)	17 (29.8)	0.078	0.576 (0.312-1.065)

BMI: Body mass index; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; Tri: Triglyceride; TC: Total cholesterol; FBG: Fasting blood glucose; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen.

Table 2 Risk factors for ampullary cancer: Univariate and multivariate logistic regression analysis using the fisher exact test n (%)

	Controls	Cases	Univariate		Multivariate
	Controls	Cases	P value	OR (95%CI)	P value	OR (95%CI)
Age
< 50 yr	100 (16.1)	20 (16.1)	1 (reference)
≥ 50 yr	520 (83.9)	104 (83.9)	1	1.000 (0.592–1.689)
Gender
Female	259 (41.8)	52 (41.9)	1 (reference)
Male	361 (58.2)	72 (58.1)	1	1.000 (0.681–1.488)
Smoking
No	448 (72.3)	86 (69.4)	1 (reference)
Yes	172 (27.7)	38 (30.6)	0.513	1.151 (0.756-1.752)
Alcohol drinking
No	453 (73.1)	88 (70.9)	1 (reference)
Yes	167 (26.9)	36 (29.1)	0.659	1.110 (0.724-1.700)
HBV
HBsAg–/anti-HBc–	295 (47.6)	84 (67.7)	1 (reference)
HBsAg+/anti-HBc+	15 (2.4)	2 (1.6)	0.546	0.468 (0.105–2.088)
HBsAg–/anti-HBc+	310 (50.0)	38 (30.6)	0	0.430 (0.284–0.652)
Diabetes mellitus					0.021	4.75 (2.739-9.853)
No	550 (88.7)	99 (79.8)	1 (reference)
Yes	70 (11.3)	25 (20.2)	0.011	1.984 (1.198–3.285)
Hypertension
No	452 (72.9)	93 (75.0)	1 (reference)
Yes	168 (27.1)	31 (25.0)	0.659	0.897 (0.576–1.397)
Cholecystolithiasis					0	14.06 (6.82-28.986)
No	592 (95.5)	160 (76.2)	1 (reference)
Yes	28 (4.5)	50 (23.8)	0	12.469 (7.37–21.095)
Cholecystectomy
No	597 (96.3)	113 (91.1)	1 (reference)
Yes	23 (3.7)	11 (8.9)	0.018	2.527 (1.198–5.328)
Chronic pancreatitis					0.038	8.863 (1.132-69.388)
No	618 (99.7)	117 (94.4)	1 (reference)
Yes	2 (0.3)	7 (5.6)	0	18.487 (3.793–90.10)
TC (mmol/L)					0	5.303 (2.188-12.853)
< 5.70	536 (86.5)	73 (58.9)	1 (reference)
≥ 5.70	84 (13.5)	51 (41.1)	0	4.458 (2.914-6.821)
Tri (mmol/L)
< 1.7	415 (66.9)	63 (50.8)	1 (reference)
≥ 1.7	205 (30.1)	61 (49.2)	0.001	1.960 (1.327-2.894)
HDL (mmol/L)					0	4.053 (2.122-7.741)
< 0.93	522 (84.2)	52 (41.9)	1 (reference)
≥ 0.93	98 (15.8)	72 (58.1)	0	7.375 (4.861-11.19)
LDL (mmol/L)
< 3.63	520 (83.9)	75 (60.5)	1 (reference)
≥ 3.63	100 (16.1)	49 (39.5)	0	3.397 (2.235-5.165)
FBG (mmol/L)
< 6.1	512 (82.6)	82 (66.1)	1 (reference)
≥ 6.10	108 (17.4)	42 (33.9)	0	2.428 (1.586-3.717)
Apo a (g/L)					0	48.58 (19.126-123.393)
< 1	612 (98.7)	59 (47.6)	1 (reference)
≥ 1	8 (1.3)	65 (52.4)	0	84.280 (38.578-184.121)
Apo b (g/L)
< 1	463 (74.7)	66 (53.2)	1 (reference)
≥ 1	157 (25.3)	58 (46.8)	0	2.592 (1.743-3.853)
BMI (kg/m²)
< 25.0	364 (58.7)	67 (54.1)	1 (reference)
≥ 25.0	256 (41.3)	57 (45.9)	0.37	1.210 (0.821-1.782)

Citation: He XD, Wu Q, Liu W, Hong T, Li JJ, Miao RY, Zhao HT. Association of metabolic syndromes and risk factors with ampullary tumors development: A case-control study in China. World J Gastroenterol 2014; 20(28): 9541-9548
URL: https://www.wjgnet.com/1007-9327/full/v20/i28/9541.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i28.9541