Hepatitis B surface antigen levels during natural history of chronic hepatitis B: A Chinese perspective study

doi:10.3748/wjg.v20.i27.9178

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2014; 20(27): 9178-9184
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9178

Table 1 Definitions of phases of persistent hepatitis B virus infection

Phase	HBV-DNA (IU/mL)	HBeAg status	ALT (U/L)	Liver imaging
IT	> 10⁷	+	≤ ULN	No cirrhosis
IC	> 2000	+	≥ 2ULN	No cirrhosis
ENH	> 2000	-	≥ 2ULN	No cirrhosis
LR	< 2000	-	≤ ULN	No cirrhosis
LC	Any	+/-	Any	Cirrhosis

IT: Immune tolerance phase; IC: Immune clearance phase; ENH: HBeAg(-) hepatitis; LR: Low-replicative; LC: Liver cirrhosis induced by hepatitis B virus; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; ULN: Upper limit of normal; “+”: Positive; “-”: Negative.

Table 2 Baseline population characteristics

	Immune tolerant	Immune clearance	HBeAg negative hepatitis	Low replicative	Liver cirrhosis	P value
HBeAg status	Positive	Positive	Negative	Negative	Positive/negative
Sex M/F	60/48	127/34	124/25	95/40	50/20	< 0.001
Age (yr)	26 (18-44)	29 (18-45)	41 (22-60)	39 (22-65)	49 (26-65)	< 0.001
ALT (U/L)	25 (9-40)	188 (80-1322)	40 (80-3755)	23 (17-39)	45 (9-341)	< 0.001
AST (U/L)	20 (6-36)	100 (7-1063)	228 (20-2136)	14 (9-38)	49 (10-302)	< 0.001
HBsAg (log₁₀ IU/mL)	4.85 (3.97-5.15)	4.36 (3.08-5.25)	2.95 (0.82-4.89)	3.18 (2.53-3.60)	2.69 (2.20-4.04)	< 0.001
HBV DNA (log₁₀ IU/mL)	8.50 (7.12-9.49)	7.93 (3.93-9.23)	5.73 (3.3-9.28)	2.64 (2.18-3.30)	4.68 (3.28-8.75)	< 0.001
Genotype
B/C	60/48	83/78	86/62	74/61	37/33	0.006

HBsAg: Hepatitis B s antigen; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; ALT: Alanine transaminase; AST: Aspartate aminotransferase.

Table 3 Correlation between hepatitis B s antigen and laboratory parameters in different phases

	IT (n = 108)		IC (n = 161)		ENH (n = 149)		LR (n = 135)		LC (n = 70)
	r	P value	r	P value	r	P value	r	P value	r	P value
Age	0.153	0.144	0.025	0.757	-0.053	0.519	-0.102	0.319	0.254	0.134
HBV-DNA (log₁₀ IU/mL)	0.287	0.003	0.683	< 0.001	0.342	< 0.001	0.156	0.071	0.177	0.143
ALT (U/L)	-0.119	0.107	-0.102	0.198	0.102	0.215	-0.057	0.422	-0.093	0.445
AST (U/L)	0.060	0.535	-0.072	0.161	0.034	0.681	-0.011	0.880	-0.082	0.499

HBV: Hepatitis B virus; IT: Immune tolerance phase; IC: Immune clearance phase; ENH: Hepatitis B e antigen negative hepatitis; LR: Low-replicative; LC: Liver cirrhosis induced by HBV.

Citation: Zeng LY, Lian JS, Chen JY, Jia HY, Zhang YM, Xiang DR, Yu L, Hu JH, Lu YF, Zheng L, Li LJ, Yang YD. Hepatitis B surface antigen levels during natural history of chronic hepatitis B: A Chinese perspective study. World J Gastroenterol 2014; 20(27): 9178-9184
URL: https://www.wjgnet.com/1007-9327/full/v20/i27/9178.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i27.9178