Lipid levels in serum and cancerous tissues of colorectal cancer patients

Table 1 Comparison of serum lipid levels in patients with colorectal cancer, patients with benign colorectal disease and healthy participants (mmol/L)

Items	Patients with colorectal cancer (n = 260)	Patients with benign colorectal disease (n = 70)	Healthy participants (n = 300)	P value
TCH	4.8 ± 0.912	5.9 ± 0.7	5.7 ± 0.9	< 0.05 < 0.01
FCH	1.9 ± 0.412	1.3 ± 0.3	1.2 ± 0.4	< 0.01 < 0.01
TG	1.5 ± 0.9	1.4 ± 0.5	1.5 ± 0.7	> 0.05
HDL-C	1.4 ± 0.4	1.4 ± 0.2	1.4 ± 0.3	>0.05
LDL-C	3.1 ± 0.812	3.9 ± 0.8	4.3 ± 0.8	< 0.01 < 0.01
ApoA-I (g/L)	1.4 ± 0.212	2.1 ± 0.4	2.2 ± 1.5	< 0.01 < 0.001
ApoB (g/L)	0.9 ± 0.312	1.8 ± 0.2	1.7 ± 0.3	< 0.01 < 0.01

¹Comparison between patients with colorectal cancer and patients with benign colorectal disease, P < 0.05 and P < 0.01, respectively;

²Comparison between patients with colorectal cancer and healthy participants, P < 0.01 and P < 0.01, respectively. ApoA-1: Apolipoprotein A1; ApoB: Apolipoprotein B; FCH: Free cholesterol; HDL-C: High density lipoprotein-cholesterol: LDL-C: Low density lipoprotein-cholesterol; TCH: Total cholesterol; TG: Triglyceride.

Table 2 Lipid levels in cancerous tissue and paracancerous tissue in patients with colorectal cancer (μmol/g)

Group	Cancerous tissue (n = 152)	Paracancerous tissue (n = 152)	P value
TCH	17.8 ± 10.7	23.6 ± 18.9	< 0.05
FCH	14.5 ± 9.6	19.3 ± 13.9	< 0.01
TG	16.3 ± 19.8	44.1 ± 38.1	< 0.001
HDL-C	7.9 ± 4.5	5.7 ± 3.9	< 0.01
LDL-C	4.4 ± 3.1	4.9 ± 3.3	> 0.05

FCH: Free cholesterol; HDL-C: High density lipoprotein-cholesterol: LDL-C: Low density lipoprotein-cholesterol; TCH: Total cholesterol; TG: Triglyceride.

Table 3 Correlations between serum lipid levels and cancerous tissue of patients with colorectal cancer with the tumor node metastasis stages

Groups	Case (n)	TCH	FCH	TG	HDL-C	LDL-C
Tissue (μmol/g)
I	15	18.3 ± 4.2	14.4 ± 8.3	17.2 ± 10.9	5.1 ± 4.3	3.9 ± 2.3
II	66	17.9 ± 3.6	15.2 ± 9.7	16.5 ± 12.2	5.7 ± 3.6	4.2 ± 2.9
III	53	16.3 ± 4.0	15.9 ± 13.4	14.9 ± 13.3	7.2 ± 5.2	4.5 ± 3.4
IV	18	13.5 ± 5.3a	13.1 ± 9.2	13.4 ± 9.4a	9.3 ± 3.2a	4.2 ± 2.7
Serum (mmol/L)
I	25	5.9 ± 0.8	1.5 ± 0.2	2.8 ± 1.1	1.5 ± 0.4	3.5 ± 1.3
II	113	4.8 ± 0.9	1.4 ± 0.3	1.9 ± 0.7	1.4 ± 0.3	3.1 ± 0.9
III	91	4.1 ± 1.0	1.4 ± 0.4	1.5 ± 0.9	1.4 ± 0.3	3.0 ± 0.9
IV	31	3.9 ± 0.9d	1.3 ± 0.4	1.3 ± 0.5d	1.1 ± 0.6	3.0 ± 0.8

^aP < 0.05 vs the levels of total cholesterol (TCH) and high density lipoprotein-cholesterol (HDL-C) in cancerous tissues with tumor node metastasis (TNM) stages;

^dP < 0.01 vs the levels of TCH and triglyceride (TG) in serum with TNM stages. LDL-C: Low density lipoprotein-cholesterol.

Table 4 Lipid levels in serum and cancerous tissues of patients with and without lymph node metastasis

Group	Case (n)	TCH	FCH	TG	HDL-C	LDL-C
Tissue (μmol/g)
With lymph node metastasis	74	18.4 ± 3.4	16.0 ± 13.4	14.9 ± 10.3	8.9 ± 3.8	4.5 ± 3.4
Without lymph node metastasis	78	17.5 ± 4.1	15.1 ± 11.6	17.7 ± 12.2	7.0 ± 4.9	4.2 ± 2.9
P		< 0.051	> 0.05	< 0.011	< 0.051	> 0.05
Serum (mmol/L)
With lymph node metastasis	127	3.2 ± 0.9	1.5 ± 0.4	1.5 ± 1.1	1.0 ± 0.4	3.2 ± 0.8
Without lymph node metastasis	133	4.9 ± 1.0	1.4 ± 0.3	1.5 ± 0.7	1.5 ± 0.4	3.0 ± 0.7
P		< 0.012	< 0.052	> 0.05	< 0.012	> 0.05

¹Indicates the comparison between lipid levels in cancerous tissue of patients with and without lymph node metastasis;

²Indicates the comparison between lipid levels in serum of patients with and without lymph node metastasis. FCH: Free cholesterol; HDL-C: High density lipoprotein-cholesterol; LDL-C: Low density lipoprotein-cholesterol; TCH: Total cholesterol; TG: Triglyceride.