Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin

doi:10.3748/wjg.v20.i25.8229

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2014; 20(25): 8229-8236
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8229

Table 1 Four siRNA duplexes targeting Girdin

siRNA	Synthetic siRNA sequence
siRNA1	Sense: CCAGAAUGUACCGAGAUGAUU
siRNA1	Antisense: UCAUCUCGGUACAUUCUGGUU
siRNA2	Sense: CUUCAUUAGUUCUGCGGGAUU
siRNA2	Antisense: UCCCGCAGAACUAAUGAAGUU
siRNA3	Sense: GGACCAACCUUGAUGAAUAUU
siRNA3	Antisense: UAUUCAUCAAGGUUGGUCCUU
siRNA4	Sense: CAAGAGUUGAGGAAUUAAAUU
siRNA4	Antisense: UUUAAUUCCUCAACUCUUGUU
scramble siRNA	Sense: GAGGCGAAACGCTAAATATCT
scramble siRNA	Antisense: AGATATTTAGCGTTTCGCCTC

Table 2 Top 10 downregulated and upregulated genes in Lv-Girdin shRNA infected DLD1 cell line vs Lv-scramble shRNA infected DLD1 cell lines

Gene name	P value	Ratio
Downregulated
TOP2B	0.000148	0.780296
EIF3E	0.000154	0.794333
SCARNA9	0.000166	0.768316
SEMA3A	0.000227	0.781830
IKZF2	0.000296	0.712167
KIT	0.000311	0.792173
MIR34A	0.000358	0.783264
LRRC37A4	0.000366	0.661987
LRRC37A4	0.000391	0.66294
ARHGAP18	0.000400	0.756169
Upregulated
PPP1R15A	0.000114	1.504745
TAP2	0.000117	1.217997
FOSL2	0.000151	1.228042
KRTAP2-1	0.000170	1.588156
TNFRSF9	0.000170	5.843542
BCL3	0.000185	1.369511
LCN2	0.000195	5.641935
CYB561D2	0.000196	1.203703
SERPINE2	0.000204	1.247110
RAB15	0.000205	1.353464

Citation: Zhang YJ, Li AJ, Han Y, Yin L, Lin MB. Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin. World J Gastroenterol 2014; 20(25): 8229-8236
URL: https://www.wjgnet.com/1007-9327/full/v20/i25/8229.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i25.8229