Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity

Table 1 MicroRNAs associated with Toll-like receptor signaling pathways, upregulated by 5-fold or greater in HepG2.2.15 than in HepG2

MicroRNAs	Genomic location	Fold changes	Description of target molecules/pathways	Ref.
miR-200b-3p	1p36.33	140.15	TLR4 signaling through MyD88-dependent pathway	[47]
miR-148a-3p	7p15.2	73.36	TLR3, TLR4 and TLR9 agonists upregulated miR-148/152 expression	[48]
miR-145-5p	5q32	66.97	miR-145 promoted interferon-β induction by SOCS7	[49]
miR-146b-5p	10q24.32	20.05	TNF receptor-associated factor 6 and IL-1 receptor-associated kinase 1	[50]
miR-200c-3p	12p13.31	10.75	TLR4 signaling through MyD88-dependent pathway	[47]
miR-455-3p	9q32	7.36	miR-455 was involved in TLR4 signaling pathway through E2F1 transcription factor	[51]
miR-455-5p	9q32	5.76	miR-455 was involved in TLR4 signaling pathway through E2F1 transcription factor	[51]

Genomic location was analyzed using GeneCards (http://gene4.weizmann.ac.il/). TLR: Toll-like receptor.

Table 2 MicroRNAs associated with Toll-like receptor signaling pathways, downregulated by 5-fold or greater in HepG2.2.15 than in HepG2

MicroRNAs	Genomic location	Fold changes	Description of target molecules/pathways	Ref.
let-7e-5p	19q13.33	-7.29	Akt1 activated by TLR4-ligand LPS, positively regulated let-7e	[52]
let-7a-3p	9q22.32	-11.44	Repression of let-7 family relieves IL-6 and IL-10 mRNAs from negative post-transcriptional control in TLR4 signaling pathway	[53]
	11q24.1
	22q13.31
let-7i-3p	12q14.1	-11.57	let-7i regulates Toll-like receptor 4 expression	[54]
let-7a-5p	9q22.32 11q24.1 22q13.31	-11.96	Repression of let-7 family relieves IL-6 and IL-10 mRNAs from negative post-transcriptional control in TLR4 signaling pathway	[53]
let-7d-5p	9q22.32	-14.03	Repression of let-7 family relieves IL-6 and IL-10 mRNAs from negative post-transcriptional control in TLR4 signaling pathway	[53]
let-7i-5p	12q14.1	-15.10	let-7i regulates Toll-like receptor 4 expression	[54,55]
miR-132-3p	17p13.3	-18.18	TNF receptor-associated factor 6 and IL-1 receptor-associated kinase 1	[56]
let-7b-5p	22q13.31	-116.31	let-7b activates TLR 7	[56]

Genomic location was analyzed using GeneCards (http://gene4.weizmann.ac.il/). TLR: Toll-like receptor.