Prognostic significance of SUVmax and serum carbohydrate antigen 19-9 in pancreatic cancer

Table 1 Standardized maximum uptake value or serum carbohydrate antigen 19-9 of pancreatic cancer stratified by stage, differentiation, lymph node and tumor size

	n	SUVmax (n = 80)		Serum CA19-9 (n = 80)
		mean ± SE	P value	mean ± SE	P value
Sex
Male	48	5.73 ± 0.36	0.091	749.30 ± 72.99	0.102
Female	32	6.91 ± 0.64		981.31 ± 132.74
Age (yr)
≤ 60	37	5.74 ± 0.42	0.206	766.43 ± 93.14	0.316
> 60	43	6.60 ± 0.52		907.22 ± 101.44
Pancreatic location (n)
Head	62	6.39 ± 0.41	0.293	871.46 ± 84.01	0.437
Body or tail	18	5.53 ± 0.50		740.99 ± 108.47
Stage
I/II	55	5.83 ± 0.43	0.110	729.09 ± 71.31	0.035
III/IV	25	7.01 ± 0.49		1090.74 ± 148.23
Pathological differentiation
Well	28	5.46 ± 0.52	0.110	720.83 ± 99.27	0.055
Moderate	18	5.81 ± 0.62		667.87 ± 126.90
Poor	34	0.70 ± 0.57		1034.22 ± 119.19
Tumor size
> 2 cm	56	6.32 ± 0.40	0.584	901.61 ± 87.16	0.193
≤ 2 cm	24	5.91 ± 0.65		703.27 ± 108.27
Lymph node metastasis
Yes	34	6.54 ± 0.52	0.017	831.84 ± 90.02	0.172
No	25	4.72 ± 0.50		634.35 ± 112.96
Distant metastasis
Yes	8	7.48 ± 0.89	0.210	1363.26 ± 338.95	0.134
No	72	6.06 ± 0.36		784.20 ± 65.13
R0 surgical resection
Yes	59	5.79 ± 0.38	0.043	731.19 ± 71.35	0.007
No	21	7.35 ± 0.67		1153.72 ± 156.96

SUVmax: Standardized maximum uptake value; CA19-9: Carbohydrate antigen 19-9.

Table 2 Univariate analysis of prognostic factors for overall survival

Variable	n	P value
Sex
Male	48	0.119
Female	32
Age (yr)
≤ 60	37	0.993
> 60	43
Pancreatic location (n)
Head	62	0.378
Body or tail	18
Stage
I/II	55	< 0.001
III/IV	25
Pathological differentiation
Well	28	0.697
Moderate	18
Poor	34
Tumor size
> 2cm	56	0.339
≤ 2cm	24
Lymph node metastasis
Yes	34	0.043
No	25
Distant metastasis
Yes	8	< 0.001
No	72
Surgical resection
Yes	59	< 0.001
No	21
SUVmax
High	40	< 0.001
Low	40
CA19-9
High	40	0.001
Low	40
SUVmax plus CA19-9
Both are high	29	0.002
Others	51

SUVmax: Standardized maximum uptake value; CA19-9: Carbohydrate antigen 19-9.

Table 3 Multivariate analysis of prognostic factors for overall survival

Variable	Hazard ratio (95%CI)	P value
Stage	0.452 (0.192-1.064)	0.020
Lymph node metastasis	0.786 (0.418-1.478)	0.455
Surgical resection	11.521 (0.799-166.191)	0.073
SUVmax	0.553 (0.216-1.413)	0.216
CA19-9	0.452 (0.192-1.064)	0.069
SUVmax plus CA19-9	1.558 (0.439-5.525)	0.493

SUVmax: Standardized maximum uptake value; CA19-9: Carbohydrate antigen 19-9.