Growth inhibition of hepatocellular carcinoma tumor endothelial cells by miR-204-3p and underlying mechanism

Table 1 Differentially expressed transcripts (up-regulated)

Name	Normalized intensity		CV		Log2 (Ratio)	P value
	HSEC	TEC	HSEC	TEC	TEC/HSEC	TEC/HSEC
hsa-miR-1	68.257645	186.191599	0.029597	0.068251	1.447725	0.000086
hsa-miR-3127-5p	131.708413	205.954953	0.021898	0.041495	0.644981	0.000128
hsa-miR-3146	126.901537	261.084309	0.090416	0.054737	1.040806	0.000266
hsa-miR-3198	115.365033	179.95054	0.020914	0.063584	0.641394	0.000680
hsa-miR-3673	71.141771	126.901537	0.023094	0.050363	0.834941	0.000125
hsa-miR-4701-5p	494.146893	744.766395	0.047938	0.083445	0.591848	0.002918

There are 6 miRNAs with increased expression in hepatocellular carcinoma TECs. Selection criteria to identify differentially expressed genes are established at log2|Fold change| ≥ 0.585 and P < 0.05. HSECs: Hepatic sinusoidal endothelial cells; TECs: Tumor endothelial cells.

Table 2 Differentially expressed transcripts (down-regulated)

Name	Normalized intensity		CV		Log2 (Ratio)	P value
	HSEC	TEC	HSEC	TEC	TEC/HSEC	TEC/HSEC
hsa-miR-1224-5p	320.137967	213.236189	0.040860	0.040824	-0.586241	0.000285
hsa-miR-204-3p	583.554793	305.8119	0.066696	0.115901	-1.233477	0.000307
hsa-miR-3178	638.353184	271.486074	0.084331	0.052030	-0.932224	0.000313
hsa-miR-3960	2801.44755	1866.07669	0.118070	0.118846	-0.586164	0.014876
hsa-miR-4488	1266.13124	816.538576	0.075747	0.081919	-0.632834	0.003703
hsa-miR-4497	5067.40908	2926.01657	0.111816	0.104477	-0.792310	0.003316
hsa-miR-4521	137.476665	89.455182	0.063787	0.037967	-0.619950	0.000703
hsa-miR-4649-5p	8288.01626	5290.33783	0.045593	0.035977	-0.647667	0.000935
hsa-miR-933	1310.3545	721.882512	0.247288	0.215769	-0.860121	0.047015

There are 9 miRNAs with decreased expression in hepatocellular carcinoma TECs. Selection criteria to identify differentially expressed genes are established at log2|Fold change| ≥ 0.585 and P < 0.05. HSECs: Hepatic sinusoidal endothelial cells; TECs: Tumor endothelial cells.