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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2014; 20(18): 5427-5434
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5427
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5427
Table 1 Distribution of genotypes and sub-genotypes among countries
Country | Genotypes | Sub-genotypes | Ref. |
China | B, C | B2, C1, C2 | Lin et al[10] |
Indonesia | C, B | C1, B3, B7, C10, B9 and C8 | Siburian et al[13] |
Prasetyo et al[14] | |||
Tunisia | D, F | - | Ayari et al[15] |
Turkey | D | D2, D1, D3 | Sunbul et al[16] |
Brazil | A, F | A1, F2a, A2, F4 | Moura et al[3] |
Nabuco et al[17] | |||
Vietnam | B, C, I | B2-5, C5-16 | Shi[18] |
Taiwan | B | B2,B5 | Kao[19] |
South Korea | C | - | Kao[19] |
Hong Kong | C,B | - | Kao[19] |
Gambia, Nigeria, Haiti, Congo, Rwanda, Cameroon | A | A4, A5, A6, A7 | Shi[18] |
Japan | A, C | C1, C2, C3 | Sakai et al[20] |
Kobayashi et al[21] | |||
Philippines | A, B, C | A1, B5, C5 | Sakamoto et al[7] |
India | A, C, D | - | Biswas et al[2] |
Canada | C, B, A, D | Congly et al[22] | |
Central African | A, D, E | A1,D4 | Komas et al[23] |
Republic | |||
Saudi Arabia | D, E | D1 | Khan et al[24] |
Iran | D | D1 | Geramizadeh et al[25] |
Norouzi et al[26] | |||
Mongolia | D | - | Oyunsuren et al[27] |
South Africa | D | D3 | Yousif et al[28] |
Thailand | C, B | C1-5 | Louisirirotchanakul et al[29] |
Italy | D | - | Lampertico et al[30] |
Morocco | D, A | D1, D7, A2 | Baha et al[31] |
Argentina | F | F1, F2, F4 | Torres et al[32] |
Egypt | D | D1 | Ragheb et al[33] |
Pakistan | D | - | Ali et al[34] |
Australia | C, D | C4, D4 | Davies et al[35] |
Sugauchi et al[36] | |||
Spain | A, D, F | - | Buti et al[37] |
Table 2 Comparison of clinical and virological features among hepatitis B virus genotypes
Genotype | B | C | A | D | E-J |
Clinical characteristics | |||||
Modes of transmission | Perinatal/vertical | Perinatal/vertical | Horizontal | Horizontal | Horizontal |
Tendency of chronicity | Lower | Higher | Higher | Lower | ND |
Positivity of HBeAg | Lower | Higher | Higher | Lower | ND |
HBeAg Seroconversion | Earlier | Later | Earlier | Later | ND |
HBsAg seroclearance | More | Less | More | Less | ND |
Histological activity | Lower | Higher | Lower | Higher | ND |
Clinical outcomes (LC, HCC) | Better | Worse | Better | Worse | Worse in genotype F |
Response to INF-α | Higher | Lower | Higher | Lower | Lower in genotype G |
Response to nucleos(t)ide analogs | No significant differences among genotypes A to D | ND | |||
Virological characteristics | |||||
Serum HBV DNA level | Lower | Higher | ND | ND | ND |
Frequency of PC A1896 mutation | Higher | Lower | Lower | Higher | ND |
Frequency of basal core promoterT1762/A1764 mutation | Lower | Higher | Higher | Lower | ND |
Frequency of preS deletion mutation | Lower | Higher | ND | ND | ND |
- Citation: Sunbul M. Hepatitis B virus genotypes: Global distribution and clinical importance. World J Gastroenterol 2014; 20(18): 5427-5434
- URL: https://www.wjgnet.com/1007-9327/full/v20/i18/5427.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i18.5427