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World J Gastroenterol. May 7, 2014; 20(17): 5124-5130
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5124
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5124
Table 1 Characteristics of the studies included in the meta-analysis
Study | Year | Country | Ethnicity | Cases | Controls | Source of controls | Type of cancer | DNA source |
Dura et al[9] | 2012 | The Netherlands | Caucasian | 349 | 581 | PB | ESCC and EADC | Blood and tissue samples |
Ihsan et al[10] | 2010 | India | Asian | 142 | 185 | PB | ESCC | Blood samples |
Jain et al[11] | 2008 | India | Asian | 107 | 320 | PB | ESCC | Blood samples |
Casson et al[16] | 2006 | Canada | Caucasian | 56 | 95 | HB | EADC | Blood samples |
Lin et al[13] | 2006 | China | Asian | 145 | 352 | PB | ESCC | Blood samples |
Zhang et al[14] | 2003 | China | Asian | 257 | 252 | HB | ESCC | Blood samples |
Wang et al[15] | 2003 | China | Asian | 62 | 38 | PB | ESCC | Tissue samples |
Table 2 Distribution of epoxide hydrolase p.Tyr113His genotypes in controls and esophageal cancer patients
Variable | Studies | Cases/controls | OR (95%CI) | P value | P for heterogeneity | I2 | Model |
Tyr/His vs Tyr/Tyr | |||||||
Total | 7 | 1118/1823 | 1.00 (0.70-1.48) | 0.928 | 0.001 | 72.8 | R |
Caucasian | 2 | 405/676 | 0.92 (0.71-1.20) | 0.555 | 0.192 | 41.2 | F |
Asian | 5 | 713/1147 | 1.14 (0.65-2.00) | 0.638 | 0.001 | 79.9 | R |
ESCC | 6 | 804/1147 | 1.08 (0.69-1.69) | 0.746 | 0.001 | 75.6 | R |
EADC | 2 | 314/676 | 0.95 (0.71-1.26) | 0.729 | 0.160 | 49.2 | F |
PB | 5 | 805/1476 | 1.04 (0.66-1.66) | 0.857 | 0.001 | 78.3 | R |
HB | 2 | 313/347 | 0.95 (0.39-2.28) | 0.902 | 0.057 | 72.4 | R |
His/His vs Tyr/Tyr | |||||||
Total | 7 | 1118/1823 | 1.10 (0.77-1.57) | 0.592 | 0.046 | 53.3 | R |
Caucasian | 2 | 405/676 | 0.74 (0.48-1.13) | 0.165 | 0.172 | 46.5 | F |
Asian | 5 | 713/1147 | 1.23 (0.94-1.60) | 0.137 | 0.120 | 45.3 | F |
ESCC | 6 | 804/1147 | 1.18 (0.92-1.52) | 0.196 | 0.158 | 37.2 | F |
EADC | 2 | 314/676 | 0.72 (0.45-1.15) | 0.163 | 0.183 | 43.7 | F |
PB | 5 | 805/1476 | 1.18 (0.78-1.78) | 0.423 | 0.079 | 52.1 | R |
HB | 2 | 313/347 | 0.78 (0.24-2.58) | 0.688 | 0.034 | 77.7 | R |
His/His + Tyr/His vs Tyr/Tyr | |||||||
Total | 7 | 1118/1823 | 1.06 (0.75-1.49) | 0.753 | 0.001 | 74.0 | R |
Caucasian | 2 | 405/676 | 0.76 (0.42-1.38) | 0.367 | 0.088 | 65.6 | R |
Asian | 5 | 713/1147 | 1.23 (0.77-1.98) | 0.382 | 0.001 | 77.8 | R |
ESCC | 6 | 804/1147 | 1.15 (0.78-1.70) | 0.484 | 0.002 | 74.0 | R |
EADC | 2 | 314/676 | 0.77 (0.41-1.46) | 0.421 | 0.074 | 68.6 | R |
PB | 5 | 805/1476 | 1.13 (0.74-1.70) | 0.575 | 0.002 | 77.0 | R |
HB | 2 | 313/347 | 0.87 (0.33-2.26) | 0.769 | 0.017 | 82.4 | R |
His/His vs Tyr/His + Tyr/Tyr | |||||||
Total | 7 | 1118/1823 | 1.09 (0.89-1.34) | 0.416 | 0.188 | 31.4 | F |
Caucasian | 2 | 405/676 | 0.77 (0.51-1.16) | 0.213 | 0.281 | 13.9 | F |
Asian | 5 | 713/1147 | 1.23 (0.97-1.55) | 0.093 | 0.388 | 3.3 | F |
ESCC | 6 | 804/1147 | 1.20 (0.95-1.50) | 0.121 | 0.469 | 0.0 | F |
EADC | 2 | 314/676 | 0.91 (0.29-2.84) | 0.878 | 0.041 | 76.1 | R |
PB | 5 | 805/1476 | 1.14 (0.89-1.45) | 0.294 | 0.210 | 31.8 | F |
HB | 2 | 313/347 | 0.97 (0.66-1.43) | 0.888 | 0.111 | 60.6 | F |
Table 3 Distribution of the microsomal epoxide hydrolase p.His139Arg genotypes in controls and esophageal cancer patients
Variable | Studies | Cases/controls | OR (95%CI) | P value | P for heterogeneity | I2 | Model |
Arg/His vs His/His | |||||||
Total | 6 | 861/1571 | 1.02 (0.84-1.23) | 0.869 | 0.176 | 34.8 | F |
Caucasian | 2 | 405/676 | 0.97 (0.74-1.27) | 0.824 | 0.955 | 0.0 | F |
Asian | 4 | 456/895 | 1.09 (0.69-1.73) | 0.709 | 0.060 | 59.4 | R |
ESCC | 5 | 547/1319 | 0.99 (0.67-1.46) | 0.954 | 0.052 | 57.5 | R |
EADC | 2 | 314/676 | 1.05 (0.79-1.40) | 0.718 | 0.755 | 0.0 | F |
PB | 5 | 805/1476 | 1.02 (0.84-1.24) | 0.833 | 0.106 | 47.5 | F |
HB | 1 | 56/95 | 0.95 (0.47-1.91) | NA | NA | NA | NA |
Arg/Arg vs His/His | |||||||
Total | 6 | 861/1571 | 0.96 (0.60-1.54) | 0.855 | 0.206 | 30.6 | F |
Caucasian | 2 | 405/676 | 0.61 (0.31-1.21) | 0.158 | 0.308 | 3.9 | F |
Asian | 4 | 456/895 | 1.59 (0.80-3.16) | 0.184 | 0.324 | 13.6 | F |
ESCC | 5 | 547/1319 | 1.28 (0.72-2.30) | 0.402 | 0.346 | 10.6 | F |
EADC | 2 | 314/676 | 0.60 (0.28-1.27) | 0.178 | 0.313 | 1.8 | F |
PB | 5 | 805/1476 | 1.08 (0.66-1.76) | 0.765 | 0.251 | 25.5 | F |
HB | 1 | 56/95 | 0.22 (0.03-1.90) | NA | NA | NA | NA |
Arg/Arg + Arg/His vs His/His | |||||||
Total | 6 | 861/1571 | 1.03 (0.78-1.37) | 0.810 | 0.095 | 46.6 | R |
Caucasian | 2 | 405/676 | 0.92 (0.71-1.20) | 0.555 | 0.719 | 0.0 | F |
Asian | 4 | 456/895 | 1.14 (0.71-1.81) | 0.593 | 0.042 | 63.5 | R |
ESCC | 5 | 547/1319 | 1.02 (0.68-1.53) | 0.918 | 0.028 | 63.1 | R |
EADC | 2 | 314/676 | 1.00 (0.75-1.31) | 0.976 | 0.550 | 0.0 | F |
PB | 5 | 805/1476 | 1.07 (0.78-1.48) | 0.676 | 0.062 | 55.5 | R |
HB | 1 | 56/95 | 0.82 (0.42-1.62) | NA | NA | NA | NA |
Arg/Arg vs Arg/His + His/His | |||||||
Total | 6 | 861/1571 | 0.97 (0.61-1.56) | 0.911 | 0.247 | 25.0 | F |
Caucasian | 2 | 405/676 | 0.62 (0.31-1.21) | 0.163 | 0.307 | 4.0 | F |
Asian | 4 | 456/895 | 1.66 (0.84-3.30) | 0.148 | 0.454 | 0.0 | F |
ESCC | 5 | 547/1319 | 1.36 (0.76-2.45) | 0.297 | 0.480 | 0.0 | F |
EADC | 2 | 314/676 | 0.58 (0.28-1.24) | 0.160 | 0.328 | 0.0 | F |
PB | 5 | 805/1476 | 1.10 (0.67-1.80) | 0.704 | 0.312 | 16.1 | F |
HB | 1 | 56/95 | 0.23 (0.03-1.91) | NA | NA | NA | NA |
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Citation: Li QT, Kang W, Wang M, Yang J, Zuo Y, Zhang W, Su DK. Association between esophageal cancer risk and
EPHX1 polymorphisms: A meta-analysis. World J Gastroenterol 2014; 20(17): 5124-5130 - URL: https://www.wjgnet.com/1007-9327/full/v20/i17/5124.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i17.5124