Copyright
©2014 Baishideng Publishing Group Co.
World J Gastroenterol. May 7, 2014; 20(17): 5008-5016
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5008
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5008
Table 1 Number of surgical interventions according to nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene status
Surgical interventions | Pathogenic mutation positive (n = 8) | Pathogenic mutation negative (n = 22) |
1 | 2 | 12 |
2 | 1 | 5 |
3 | 1 | 3 |
4 | 3 | 1 |
5 | 1 | 1 |
Table 2 Analysis of phenotypic characteristics of Crohn’s disease patients according to nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene status1
Characteristics | 3020insC mutation positive (n = 4) | 3020insC mutation negative (n = 26) |
Disease behaviour | ||
Perforating | 1 | 5 |
Stricturing | 4 | 14 |
Inflammatory | 3 | 7 |
Location of CD lesions | ||
Small bowel | 4 | 7 |
Ileocaecal | 6 | 19 |
Colonic | 1 | 7 |
Anorectal | 1 | 1 |
Others | 0 | 0 |
No of locations involved | ||
1 | 4 | 13 |
2 | 4 | 7 |
3 | 0 | 2 |
4+ | 0 | 0 |
Extraintestinal manifestations | 0 | 3 |
Table 3 Comparison of allele frequencies of nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 mutations
-
Citation: Bhullar M, Macrae F, Brown G, Smith M, Sharpe K. Prediction of Crohn’s disease aggression through
NOD2 /CARD15 gene sequencing in an Australian cohort. World J Gastroenterol 2014; 20(17): 5008-5016 - URL: https://www.wjgnet.com/1007-9327/full/v20/i17/5008.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i17.5008