Topic Highlight
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. May 7, 2014; 20(17): 4892-4899
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.4892
Table 1 Intraoperative outcomes in retrospective comparative studies concerning liver resection for hepatocellular carcinoma via laparoscopy or open approach
Ref.Laparoscopies (n)Median blood loss, mL
Blood transfusion
Median operative time, min
LOP valueLOP valueLOP value
Cheung et al[11], 2013321503000.0010%4.7%NS204232NS
Kanazawa et al[10], 201328885050.00030%4%0.0379228236NS
Lee et al[12], 201133150240NS6.1%10%NS2251950.019
Ker et al[46], 20111161391147< 0.0016.9%50.9%< 0.001156190NS
Hu et al[69], 201130520 g480 gNS---180170NS
Kim et al[70], 201126---19.2%24.1%NS1472200.031
Truant et al[13], 201136452447NS2.8%3.8%NS193215NS
Tranchart et al[9], 201042364723< 0.00019.5%16.7%NS233221NS
Aldrighetti et al[71], 2010162586170.0084%6%NS1502400.044
Belli et al[30], 200954297580< 0.0111%25.6%0.031671850.012
Lai et al[72], 200925------150135NS
Endo et al[73], 200910--NS------
Sarpel et al[74], 200920-----NS161165NS
Belli et al[48], 200723260377NS0%17.3%0.0361481250.016
Lee et al[75], 2007251002500.0124%0%NS220195NS
Kaneko et al[76], 200530350505NS---182210NS
Laurent et al[77], 200313620720NS4%28.6%NS2671820.006
Shimada et al[78], 200117400 g800 gNS5.9%10.5%NS325280NS
L: Laparoscopy; O: Open; NS: Non significant.
Table 2 Oncologic outcomes in retrospective comparative studies concerning liver resection for hepatocellular carcinoma via laparoscopy or open approach
Ref.Laparoscopies (n)Positive surgical margin
Overall survival
Recurrence-free survival
LOP valueLOP valueLOP value
Cheung et al[11], 201332---76.6%557%5NS54.5%744.3%7NS
Kanazawa et al[10], 201328---------
Lee et al[12], 2011333.0%12.0%1NS76%576.1%5NS45.3%755.9%7NS
Ker et al[46], 201111662.2%571.8%5NS---
Hu et al[69], 201130---50%553.3%5NS---
Kim et al[70], 2011263.8%13.4%NS---84.6%82.8%NS
Truant et al[13], 201136---70%546%5NS35.5%733.6%7NS
Tranchart et al[9], 201042---59.5%547.4%5NS60.9%654.3%6NS
Aldrighetti et al[71], 2010160%118.7%1NS--NS--NS
Belli et al[30], 2009540%140.8%1NS67%4-NS52%6-NS
Lai et al[72], 200925---60%4--52%6--
Endo et al[73], 200910-----NS--NS
Sarpel et al[74], 20092010%126.8%1NS--NS--NS
Belli et al[48], 2007238.6%30%3NS86.9%82.6%NS---
Lee et al[75], 200725-----NS--NS
Kaneko et al[76], 200530---61%562%5NS31%729%7NS
Laurent et al[77], 20031315.4%114.3%1NS89%455%40.0446%644%6NS
Shimada et al[78], 20011741.2%250%2NS--NS---
1Tumor at surgical surface;
2Tumor invasion < 5 mm;
3Tumor invasion < 1 cm; Overall survival at 2, 34 or 55 years; Recurrence-free survival at 2, 36 or 57 years. L: Laparoscopy; O: Open; NS: Non significant.
Table 3 Postoperative outcomes in retrospective comparative studies concerning liver resection for hepatocellular carcinoma via laparoscopy or open approach
Ref.Laparoscopies (n)Postoperative morbidity
Ascites
Mean postoperative hospital stay, d
LOP valueLOP valueLOP value
Cheung et al[11], 2013326.3%18.8%NS31.1%6.2%0.87147< 0.0001
Kanazawa et al[10], 20132810.7%71.4%< 0.00013%18% < 0.00011019< 0.0001
Lee et al[12], 2011336.1%24% 0.033---57< 0.0005
Ker et al[46], 20111166%30.2%< 0.0011.7%12.5%0.0026.212.4 0.001
Hu et al[69], 20113013.3%10%NS---1320< 0.01
Kim et al[70], 2011263.8%24.1%NS---1116 0.034
Truant et al[13], 20113625%35.8%NS13.9%22.6%0.36.59.5 0.003
Tranchart et al[9], 20104221.4%40.5%NS7.1%26.1%0.036.79.6< 0.0001
Aldrighetti et al[71], 20101625%43.7%NS0%1%NS6.39 0.039
Belli et al[30], 20095419%36%0.02---8.49.2NS
Lai et al[72], 20092516%15%NS---79 0.008
Endo et al[73], 200910--------< 0.05
Sarpel et al[74], 200920---------
Belli et al[48], 20072313%47.8%0.0113%39.1%0.0438.212 0.048
Lee et al[75], 2007254%4%NS47< 0.001
Kaneko et al[76], 20053010%18%NS---14.921.6< 0.005
Laurent et al[77], 20031336%50%NS8%36%0.1515.317.3NS
Shimada et al[78], 2001175.9%10.5%NS--NS1222< 0.001
L: Laparoscopy; O: Open; NS: Non significant.