Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats

Table 1 Macroscopic evaluation, myeloperoxidase activity, body weight and cytokine production in colon tissues

	Control	Colitis
Damage score	0 (0-1)	5 (4-9)a
Myeloperoxidase activity (U/g tissue)	2.2 ± 0.6	18.2 ± 4.8b
Initial body weight (g)	299 ± 8	303 ± 3
Final body weight (g)	405 ± 9	368 ± 4a
Microscopic score	2 (0-3)	11 (6-14)a
TNF-α (pg/mg protein)	1.8 ± 1.2	7.4 ± 2.1a
IL-6 (pg/mg protein)	8.2 ± 1.7	14.7 ± 0.7a
IL-10 (pg/mg protein)	23.5 ± 3.4	12.1 ± 1.7b

^aP < 0.05 and

^bP < 0.01 compared with the control group (n = 5-7). TNF-α:Tumor necrosis factor-alpha; IL: Interleukin.

Table 2 Hematological parameters in the control and colitis groups

	Control	Colitis
Red blood cells (106/μL)	7.6 ± 0.2	8.1 ± 0.2
Hemoglobin (g/dL)	15.2 ± 0.2	14.8 ± 0.1
Hematocrit (%)	44.1 ± 0.3	43.7 ± 0.3
White blood cells (cells/μL)	5.2 ± 0.7	8.8 ± 0.5b

^bP < 0.01 compared with the control group (n = 5).

Table 3 Serum parameters in the control and colitis groups

	Control	Colitis
Hepcidin (pg/mL)	241.9 ± 59.5	280.4 ± 65.8
Transferrin (ng/mL)	18.0 ± 0.4	20.4 ± 1.5
Iron (μg/dL)	69.0 ± 4.5	72.9 ± 10.0
Transferrin saturation (%)	26.1 ± 2.4	25.5 ± 1.2