Interval to surgery after neoadjuvant treatment for colorectal cancer

Table 1 Effect of chemoradiotherapy-surgery intervals on oncological outcome

Ref.	Year	CRT-surgery interval	Pts (n)	pCR	LR	OS
Francois et al[28] + Glehen et al[56]	1999	2/6-8 wk	201	7%/14% NS	13%/10%	69%/66%
Stein et al[43]	2003	4-8/10-14	33	21%/14%	NA	NA
Moore et al[44]	2004	≤ 44 d <	155	12%/19%	NA	NA
Coucke et al[42]	2006	≤ 5 d <	250	NA	10%/7%	47%/69%2
Supiot et al[57]	2006	≤ 6 wk <	102	NA	16%	NA
Tran et al[40]	2006	≤ 8 wk <	48	6%/9%	0%/9%	NA
Dolinsky et al[60]	2007	≤ 6-8 wk <	107	Same (P = 0.8)	11%	NA
Veenhof et al[62]	2007	2/6-8 wk1	108	0%/12%	7%/2%	64%/77%
Habr-Gama et al[61]	2008	≤ 12 wk <	250	10%/6%4	NA3	NA
Lim et al[41]	2008	28-41/42-56 d	397	13.8%/15%	8.2%3	NA
Tulchinsky et al[52]	2008	≤ 7 wk <	132	17%/35%2	6%/4%	81%/93%
Kerr et al[59]	2008	Median 76 d (6-215 d)	189	15.90%	21%	NA
de Campos-Lobato et al[53]	2011	≤ 8 wk <	177	16%/31%2	10.5%/1.2%	NA
Garcia-Aguilar et al[38]	2011	6/11 wk	136	18%/25%2	NA	NA
Evans et al[58]	2011	≤ 6-8 wk <	95	5%/12%/17%2	NA	NA
Wolthuis et al[54]	2012	≤ 7 wk <	356	16%/28%2	6%/3%	NA
Pach et al[55]	2012	7-10 d/4-5 wk1	154	0%/10.4%2	1.5%/7%	63%/73%
Sloothaak et al[36]	2013	≤ 8 wk/8-9/10-11/11 <	1593	10%/13%/18%2/11%	NA	NA

¹Short-course chemoradiotherapy (CRT);

²Statistically significant difference;

³Local and systemic recurrence;

⁴Pts with complete clinical response who were not operated were excluded. pCR: Pathological complete response; LR: Local recurrence; OS: Overall survival; NA: Not available.