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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2014; 20(13): 3655-3662
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3655
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3655
Table 1 Demographic and clinical features of patients with nonalcoholic fatty liver disease and controls n (%)
NAFLD patients(n = 390) | Controls(n = 409) | P value | |
BMI (kg/m2) | 24.83 ± 2.82 | 22.18 ± 4.02 | 0.000a |
Waist (cm) | 84.18 ± 8.19 | 75.78 ± 9.13 | 0.000a |
Hypertension | 89 (22.8) | 42 (10.3) | 0.000c |
T2DM | 87 (22.3) | 36 (8.8) | 0.000c |
ALT (U/L) | 44.86 ± 40.16 | 34.32 ± 22.27 | 0.000a |
AST (U/L) | 33.40 ± 32.60 | 32.60 ± 36.42 | 0.762 |
GGT (U/L) | 43.82 ± 42.17 | 34.00 ± 26.92 | 0.000a |
FPG (mmol/L) | 6.03 ± 1.77 | 5.18 ± 0.82 | 0.357 |
UA (mmol/L) | 326.03 ± 105.24 | 332.88 ± 104.74 | 0.000a |
TG (mmol/L) | 2.91 ± 1.43 | 2.26 ± 1.55 | 0.000a |
TC (mmol/L) | 5.17 ± 1.00 | 4.77 ± 0.85 | 0.000a |
HDL (mmol/L) | 1.71 ± 0.99 | 2.38 ± 2.36 | 0.000a |
LDL (mmol/L) | 4.28 ± 3.44 | 3.17 ± 1.78 | 0.000a |
FINS (μU/mL) | 6.27 ± 1.34 | 5.51 ± 1.01 | 0.000a |
HOMA-IR (U) | 1.67 ± 0.62 | 1.27 ± 0.32 | 0.000a |
Table 2 Distribution of genotype and allele frequencies of apolipoprotein C3 (-455, -482) and patatin-like phospholipase domain-containing protein 3 (rs738409) in nonalcoholic fatty liver disease patients and controls n (%)
NAFLD | Controls | χ2 | P value | |
-455 genotype | ||||
TT | 102 (26.2) | 104 (25.4) | ||
TC | 180 (46.2) | 195 (47.7) | ||
CC | 108 (27.7) | 110 (26.9) | 0.186 | 0.911 |
Allele T | 384 (49.2) | 403 (49.3) | ||
C | 396 (50.8) | 415 (51.2) | 0.000 | 1.000 |
-482 genotype | ||||
CC | 107 (27.4) | 104 (25.4) | ||
CT | 176 (45.1) | 203 (49.6) | ||
TT | 107 (27.4) | 102 (51.2) | 1.635 | 0.442 |
Allele C | 390 (50.0) | 411 (50.2) | ||
T | 390 (50.0) | 407 (49.8) | 0.010 | 0.960 |
rs738409 genotype | ||||
CC | 48 (12.3) | 183 (44.7) | ||
CG | 153 (39.2) | 176 (43.0) | ||
GG | 189 (48.5) | 50 (12.2) | 160.98 | 0.000 |
Allele C | 249 (31.9) | 542 (66.3) | ||
G | 531 (68.1) | 276 (33.7) | 188.31 | 0.000 |
Table 3 Odds ratios for nonalcoholic fatty liver disease according to apolipoprotein C3 and patatin-like phospholipase domain-containing protein 3 genotypes and alleles in the study population
Unadjusted model | Adjusted model | |||
OR (95%CI) | P value | OR (95%CI) | P value | |
APOC3 gene | ||||
-455TT | 1 | 1 | ||
-455TC + CC | 0.96 (0.70-1.32 ) | 0.82 | 1.06 (0.72-1.57 ) | 0.76 |
-482CC | 1 | 1 | ||
-482CT + TT | 0.90 (0.66-1.24 ) | 0.52 | 1.00 (0.68-1.48 ) | 1.00 |
PNPLA3 gene | ||||
CC | 1 | 1 | ||
CG + GG | 5.77 (4.03-8.27) | 0.00 | 3.70 (2.44-5.60) | 0.00 |
Table 4 Clinical characteristics of apolipoprotein C3 wild-type homozygotes (rs2854117 C/C and rs2854116 T/T) and carriers of one or more variant alleles (rs2854117 T and rs2854116 C) in the study population
Characteristic | Overall series | NAFLD patients | Controls | ||||||
Noncarriers | Carriers | P value | Noncarriers | Carriers | P value | Noncarriers | Carriers | P value | |
n | 197 | 602 | 96 | 294 | 101 | 308 | |||
Female/male | 110/87 | 306/296 | 0.250 | 48/48 | 157/137 | 0.638 | 62/39 | 149/159 | 0.903 |
Age (yr) | 47.95 ± 16.86 | 48.95 ± 15.76 | 0.447 | 49.16 ± 17.23 | 49.96 ± 15.83 | 0.672 | 46.80 ± 16.51 | 47.98 ± 15.65 | 0.516 |
BMI (kg/m2) | 23.69 ± 4.08 | 23.42 ± 3.73 | 0.387 | 25.21 ± 2.48 | 24.70 ± 2.91 | 0.123 | 22.14 ± 4.07 | 22.19 ± 4.10 | 0.910 |
Waist (cm) | 78.97 ± 9.56 | 80.17 ± 9.66 | 0.130 | 85.36 ± 7.11 | 83.79 ± 8.49 | 0.074 | 72.90 ± 7.40 | 76.72 ± 9.45 | 0.000 |
ALT (U/L) | 39.47 ± 34.79 | 39.46 ± 31.98 | 0.999 | 48.60 ± 44.85 | 43.64 ± 38.51 | 0.294 | 30.79 ± 17.50 | 35.48 ± 23.54 | 0.066 |
AST (U/L) | 32.71 ± 36.37 | 33.08 ± 37.72 | 0.904 | 36.35 ± 42.00 | 32.44 ± 37.14 | 0.386 | 29.25 ± 29.86 | 33.70 ± 38.31 | 0.287 |
FPG (U/L) | 5.46 ± 1.26 | 5.63 ± 1.49 | 0.135 | 5.82 ± 1.46 | 6.09 ± 1.86 | 0.201 | 5.12 ± 0.91 | 5.20 ± 0.79 | 0.435 |
TG (mmol/L) | 2.67 ± 1.68 | 2.54 ± 1.47 | 0.341 | 2.88 ± 1.29 | 2.92 ± 1.48 | 0.840 | 2.46 ± 1.97 | 2.20 ± 1.39 | 0.134 |
TC (mmol/L) | 4.97 ± 0.98 | 4.96 ± 0.94 | 0.887 | 5.18 ± 0.96 | 5.17 ± 1.01 | 0.903 | 4.77 ± 0.96 | 4.76 ± 0.81 | 0.935 |
HDL (mmol/L) | 2.25 ± 2.21 | 1.99 ± 1.72 | 0.134 | 1.51 ± 0.46 | 1.78 ± 1.10 | 0.001 | 2.96 ± 2.89 | 2.19 ± 2.14 | 0.015 |
LDL (mmol/L) | 3.84 ± 3.09 | 3.68 ± 2.66 | 0.477 | 4.43 ± 3.71 | 4.24 ± 3.35 | 0.659 | 3.28 ± 2.24 | 3.14 ± 1.61 | 0.564 |
FINS (μU/mL ) | 5.83 ± 1.20 | 5.90 ± 1.24 | 0.545 | 6.22 ± 1.24 | 6.28 ± 1.36 | 0.712 | 5.46 ± 1.03 | 5.53 ± 1.00 | 0.554 |
HOMA-IR (U) | 1.42 ± 0.43 | 1.48 ± 0.52 | 0.111 | 1.62 ± 0.57 | 1.69 ± 0.61 | 0.309 | 1.25 ± 0.34 | 1.28 ± 0.31 | 0.376 |
APOC3 (mg/dL) | 13.94 ± 2.01 (n = 34) | 14.38 ± 1.92 (n = 146) | 0.231 | 13.60 ± 1.90 (n = 19) | 14.37 ± 1.98 (n = 80) | 0.231 | 15.22 ± 1.79 (n = 15) | 14.20 ± 1.89 (n = 66) | 0.059 |
Table 5 Clinical characteristics of patatin-like phospholipase domain-containing protein 3 and apolipoprotein C3 (independently of patatin-like phospholipase domain-containing protein 3 I148M) wild-type homozygotes and carriers of one or more variant alleles in the study population
Characteristic | PNPLA3 | APOC3 (independently of PNPLA3 I148M) | ||||
Noncarriers | Carriers | P value | Noncarriers | Carriers | P value | |
n | 231 | 568 | 82 | 149 | ||
Female/male | 124/107 | 292/276 | 0.560 | 12/70 | 109/40 | 0.000 |
Age (yr) | 46.97 ± 16.42 | 49.41 ± 15.83 | 0.052 | 48.89 ± 16.91 | 45.92 ± 16.11 | 0.189 |
BMI (kg/m2) | 22.61 ± 4.08 | 23.84 ± 3.65 | 0.000 | 22.04 ± 4.17 | 22.92 ± 4.00 | 0.118 |
Waist (cm) | 75.67 ± 9.00 | 81.59 ± 9.37 | 0.000 | 72.96 ± 7.64 | 77.16 ± 9.37 | 0.000 |
ALT (U/L) | 36.03 ± 24.46 | 40.86 ± 35.40 | 0.028 | 34.67 ± 20.30 | 36.77 ± 26.51 | 0.501 |
AST (U/L) | 34.07 ± 37.80 | 32.55 ± 37.21 | 0.601 | 32.55 ± 37.21 | 34.07 ± 37.80 | 0.662 |
FPG (U/L) | 5.30 ± 1.09 | 5.71 ± 1.54 | 0.000 | 5.26 ± 0.82 | 5.33 ± 1.21 | 0.618 |
TG (mmol/L) | 2.34 ± 1.54 | 2.67 ± 1.51 | 0.005 | 2.17 ± 1.09 | 2.43 ± 1.73 | 0.216 |
TC (mmol/L) | 4.79 ± 0.90 | 5.03 ± 0.95 | 0.001 | 4.72 ± 0.76 | 4.83 ± 0.97 | 0.343 |
HDL (mmol/L) | 2.64 ± 2.54 | 1.82 ± 1.43 | 0.000 | 2.88 ± 2.63 | 2.50 ± 2.48 | 0.281 |
LDL (mmol/L) | 3.28 ± 1.98 | 3.90 ± 3.02 | 0.001 | 3.44 ± 1.92 | 3.19 ± 2.01 | 0.367 |
FINS (μU/mL) | 5.67 ± 1.13 | 5.97 ± 1.26 | 0.001 | 5.58 ± 1.02 | 5.72 ± 1.20 | 0.335 |
HOMA-IR (U) | 1.34 ± 0.38 | 1.52 ± 0.53 | 0.000 | 1.31 ± 0.33 | 1.35 ± 0.41 | 0.354 |
- Citation: Niu TH, Jiang M, Xin YN, Jiang XJ, Lin ZH, Xuan SY. Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population. World J Gastroenterol 2014; 20(13): 3655-3662
- URL: https://www.wjgnet.com/1007-9327/full/v20/i13/3655.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i13.3655