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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2014; 20(13): 3640-3648
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3640
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3640
Table 1 Overall survival by total examined lymph nodes and cut-point analysis in each subgroup
Depth of invasion | ≤ 3 vs≥ 4 | ≤ 10 vs≥ 11 | ≤ 15 vs≥ 16 | ≤ 25 vs≥ 26 | ||||
χ2 | P value | χ2 | P value | χ2 | P value | χ2 | P value | |
T1 + T2 | 8.333 | 0.004 | 9.679 | 0.002 | 11.023 | 0.001 | 0.825 | 0.364 |
T3 + T4 | 5.529 | 0.019 | 7.884 | 0.005 | 13.204 | < 0.001 | 9.476 | 0.002 |
Total | 8.711 | 0.003 | 16.589 | < 0.001 | 20.612 | < 0.001 | 5.770 | 0.016 |
Table 2 Comparison of clinicopathologic characteristics between patients with ≤ 15 and >15 examined lymph nodes n (%)
Variables | Number of examined nodes | χ2 | P value | |
≤ 15 | > 15 | |||
Total | 331 (66.6) | 166 (33.4) | ||
Gender | 11.741 | 0.001 | ||
Male | 259 (78.2) | 106 (63.9) | ||
Female | 72 (21.8) | 60 (36.1) | ||
Age at surgery (yr) | 5.355 | 0.023 | ||
≤ 60 | 155 (46.8) | 96 (57.8) | ||
> 60 | 176 (53.2) | 70 (42.2) | ||
Tumor size (cm) | 0.845 | 0.392 | ||
≤ 4 | 163 (49.2) | 89 (53.6) | ||
> 4 | 168 (50.8) | 77 (46.4) | ||
Tumor location | 8.672 | 0.034 | ||
Lower | 158 (47.7) | 98 (59.0) | ||
Middle | 31 (9.4) | 16 (9.6) | ||
Upper | 111 (33.5) | 35 (21.1) | ||
Diffuse | 31 (9.4) | 17 (7.7) | ||
Type of gastrectomy | 4.455 | 0.041 | ||
Subtotal | 284 (85.8) | 130 (78.3) | ||
Total | 47 (14.2) | 36 (21.7) | ||
Histological type | 9.694 | 0.002 | ||
Undifferentiated | 177 (53.5) | 113 (68.1) | ||
Differentiated | 154 (46.5) | 53 (31.9) | ||
Extent of lymphadenectomy | 111.652 | < 0.001 | ||
Limited | 242 (73.6) | 39 (23.6) | ||
Extended | 87 (26.4) | 126 (76.4) | ||
Extent of examined lymph nodes | 84.522 | < 0.001 | ||
Perigastric | 189 (57.1) | 23 (13.9) | ||
Extragastric | 142 (42.9) | 143 (86.1) | ||
Depth of invasion | 1.445 | 0.695 | ||
T1 | 21 (6.3) | 13 (7.8) | ||
T2 | 59 (17.8) | 35 (21.1) | ||
T3 | 47 (14.2) | 24 (14.5) | ||
T4 | 204 (61.6) | 94 (56.7) | ||
TNM Classification 7th | 1.738 | 0.784 | ||
Ia | 21 (6.3) | 13 (7.8) | ||
Ib | 59 (17.8) | 35 (21.1) | ||
IIa | 47 (14.2) | 24 (14.5) | ||
IIb | 196 (59.2) | 89 (53.6) | ||
IIIb | 8 (2.4) | 5 (3.0) |
Table 3 Univariate and multivariate survival analyses of 497 node-negative gastric cancer patients
Variables | 5-YSR | Univariate analysis | Multivariate analysis | ||
χ2 | P value | HR (95%CI) | P value | ||
Gender | 1.213 | 0.271 | |||
Male | 66.0 | ||||
Female | 70.4 | ||||
Age at surgery (yr) | 2.720 | 0.099 | |||
≤ 60 | 70.1 | ||||
> 60 | 64.2 | ||||
Tumor size (cm) | 3.548 | 0.060 | |||
≤ 4 | 71.0 | ||||
> 4 | 63.2 | ||||
Tumor location | 0.167 | 0.682 | |||
Upper | 69.9 | ||||
Middle | 53.2 | ||||
Lower | 69.5 | ||||
Diffuse | 60.4 | ||||
Type of gastrectomy | 2.045 | 0.153 | |||
Subtotal | 68.3 | ||||
Total | 61.4 | ||||
Histological type | 0.117 | 0.732 | |||
Undifferentiated | 67.9 | ||||
Differentiated | 66.2 | ||||
Extent of lymphadenectomy | 6.093 | 0.014 | |||
Limited | 63 | ||||
Extended | 73.2 | ||||
Extent of examined lymph nodes (LNs) | 12.112 | 0.001 | |||
Perigastric | 58.9 | ||||
Extragastric | 73.3 | ||||
Depth of invasion | 22.355 | < 0.001 | < 0.001 | ||
T1 | 88.2 | 1 | |||
T2 | 79.8 | 1.801 (0.613-5.293) | 0.285 | ||
T3 | 74.6 | 2.102 (0.703-6.287) | 0.184 | ||
T4 | 59.1 | 4.066 (1.502-11.007) | 0.006 | ||
Number of examined LNs | 32.690 | < 0.001 | 0.334 (0.221-0.506) | < 0.001 | |
≤ 15 | 58.6 | 1 | |||
> 15 | 84.3 | 0.327 (0.216-0.495) | < 0.001 | ||
TNM Classification 7th | 22.541 | < 0.001 | |||
Ia | 88.2 | ||||
Ib | 79.8 | ||||
IIa | 74.6 | ||||
IIb | 59.3 | ||||
IIIb | 53.8 |
Table 4 Five-year overall survival by T stage subgroups and total number of examined lymph nodes
Variables | Number of examined nodes (n) | χ2 | P value | |||
1-3 | 4-10 | 11-15 | ≥ 16 | |||
Depth of invasion | ||||||
T1 | 60.0% | 91.7% | - | 92.3% | 4.598 | 0.204 |
T2 | 58.3% | 68.2% | 84.0% | 91.4% | 9.668 | 0.022 |
T3 | 50.0% | 63.3% | 81.8% | 91.7% | 8.738 | 0.033 |
T4 | 35.1% | 48.6% | 62.5% | 78.7% | 31.487 | < 0.001 |
Total | 43.3% | 56.6% | 71.8% | 84.3% | 51.837 | < 0.001 |
Table 5 Recurrent sites of node-negative gastric cancer in terms of ≤ 15 and > 15 examined lymph nodes n (%)
Recurrent sites | Number of examined nodes | χ2 | P value | |
≤ 15 | > 15 | |||
Recurrence | 4.491 | 0.043 | ||
Yes | 65 (19.6) | 20 (12.0) | ||
No | 266 (80.4) | 146 (88.0) | ||
Locoregional recurrence | 4.362 | 0.048 | ||
Yes | 37 (11.2) | 9 (5.4) | ||
No | 294 (88.8) | 157 (94.6) | ||
Peritoneal seeding | 4.874 | 0.037 | ||
Yes | 24 (7.3) | 4 (2.4) | ||
No | 307 (92.7) | 162 (97.6) | ||
Hematogenous spread | 1.740 | 0.239 | ||
Yes | 24 (7.3) | 7 (4.2) | ||
No | 307 (92.7) | 159 (95.8) |
- Citation: Jiao XG, Deng JY, Zhang RP, Wu LL, Wang L, Liu HG, Hao XS, Liang H. Prognostic value of number of examined lymph nodes in patients with node-negative gastric cancer. World J Gastroenterol 2014; 20(13): 3640-3648
- URL: https://www.wjgnet.com/1007-9327/full/v20/i13/3640.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i13.3640