Classifying extrahepatic bile duct metachronous carcinoma by de novo neoplasia site

Table 1 Clinical features of the patients with metachronous cancer of the bile duct described in the literature

Ref.	Year published	Age (yr)	Sex	Site of	Type of	Time to	Site of	Type of	Type of	Status
				1st tumor	1st surgery1	2nd tumor	2nd tumor1	2nd surgery2	meta-BDCA
Todoroki et al[11]	1993	67	F	Perihilar	LH with RYHJ	13 Y	IHBD	RPMS	Type 1a	Alive, 3 Y 5 M
Seki et al[12]	1998	68	M	Dist. BD	PD	12.8 Y	Prox. BD.	ERH+α	Type 2	Dead, 6 M
	1998	69	F	Dist. BD	PD	5.8 Y	Prox. BD	RH	Type 2	Alive, 17 M
Saiura et al[10]	1999	75	F	IHBD	LH extended	7 Y	Dist. BD	PD	Type 1a	Alive, 36 M
Nakakubo et al[13]	2001	49	F	BD	PD	4 Y	Prox. BD.	LH ext.	Type 2	Dead, 14 M
Okamoto et al[14]	2003	42	F	BD	Excision of cyst	3 Y	Right HD	RH	Type 1a	Alive 11.2 Y
	2003	62	M	BD	PD	3.5 Y	Left HD	LH	Type 2	Alive 2 Y
Yoon et al[15]	2005	50	F	Diffuse	BDR	5.5 Y	Prox. and Dist. BD	HPD	Type 1c	Alive, 46 M
	2005	29	F	Prox. BD	RH with RYHJ	2.3 Y	Dist. BD	PD	Type 1b	Alive, 9 M
Hibi et al[16]	2006	65	M	Mid. to Dist. BD	PD	3 Y	Prox. BD	RH	Type 2	Alive, 8 M
Merenda et al[4]	2007	65	M	Middle BD.	BDR	2.3 Y	Dist. BD	PD	Type 1b	Alive, 6 M
Present Case 1	2013	70	F	Prox. BD	BDR	14 M	Dist. BD	PD	Type 1b	Alive, 6 Y
Present Case 2	2013	70	M	Middle BD	BDR	24 M	Dist. BD	PD	Type 1b	Alive, 16 M

¹In all cases, the resection margin was free from tumor after the 1^st surgery,

²In all cases, the resection margin was free from tumor after the 2^nd surgery. RH: Roux-en-Y hepaticojejunostomy; IHBD: Intrahepatic bile duct; RPMS: Right paramedian sectorectomy; BD: Bile duct; BDR: Bile duct resection; HPD: Hepatopancreaticoduodenectomy; ERH + α: Extended right hepatectomy with partial gastrectomy and limited resection of segment 3 due to a metastatic liver tumor; LH: Left hepatectomy.