Medicinal plants against hepatitis C virus

Table 1 Medicinal plant phytochemicals as anti- hepatitis C virus agents

Phytochemicals	Viral step	Effect
Diosgenin[43]	Replication	Inhibition of transcription factor 3 and signal transducer
Silymarin/silibinin[37,44,45]	Viral entry (viral attachment) Replication	Inhibition of core protein and NS5 RNA-dependent RNA polymerase
Iridoids[46,47]	Viral entry	Blockage of E2 and CD81 contact
Naringenin[48,49]	Viral assembly	Suppression of core protein activity
EGCG[50,51]	Viral entry	Disturbance in glycoprotein activity and Inhibition of cell-cell transmission
Quercetin[52,53]	Replication	Inhibition of IRES activity and NS3 polymerase
Ladanein[54]	Post attachment entry step	Inhibition of receptor interactions, virus endocytosis, or membrane fusion
Luteolin and apigenin[55]	Replication	Inhibition of NS5B polymerase activity

IRES: Internal ribosomal entry site. EGCG: Epigallocatechin gallate.