Immunopathology of inflammatory bowel disease

doi:10.3748/wjg.v20.i1.6

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2014; 20(1): 6-21
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.6

Table 1 Innate lymphoid cell subsets

ILCs	Lineage	Mouse	Human	Cytokines	Function	Disease
Group 1	ILC1s	Lin^-Thy1⁺Sca1⁺Tbet⁺	Lin^-CD56⁺NKp46⁺NKp30⁺NKp44⁺IL-7R^-	IFN-γ	Inflammation	IBD?
Group 1	NK cells	NKp46⁺NK1.1⁺CD122⁺NKG2D⁺CD161⁺CD16⁺	CD122⁺NKG2D⁺CD161⁺KIR⁺	IFN^-, TNF-α, cytotoxic effectors	Immunity to viruses and intracellular pathogens, tumor surveillance	Inflammatory conditions, IBD
Group 2	ILC2s	Lin^-ICOS⁺Thy1⁺Sca1⁺IL-7R⁺GATA3⁺	Lin^-IL-7R⁺CD45^hiCD161⁺ CRTH2⁺	IL-5, IL-9, IL-13	Immunity to helminthes, wound healing	Allergy, asthma
Group 3	ILC3s	Lin^-Thy1⁺Sca1⁺RORt⁺NKp46⁺IL-7R⁺CCR6^-	Lin^-CD56^-NKp46⁺NKp30⁺NKp44⁺IL-7R⁺	IL-22	Lymphoid tissue development, intestinal homeostatsis, immunity to extracellular bacteria	IBD
Group 3	LTi cells	Lin^-Thy1⁺Sca1⁺RORt⁺NKp46^-IL-7R⁺CCR6⁺	Lin^-IL-7R⁺CD45⁺RORt⁺	IL-17A, IL-17F, IL-22	Homeostasis of epithelia, immunity to extracellular bacteria	IBD

Lin^-: Lineage marker negative (mouse negative for CD3, CD19, B220, CD11b, CD11c, GR1, Ter11; human negative for CD1a, CD3, CD11c, CD34, CD123, TCR, TCR, CD19, CD14, CD16); IBD: Inflammatory bowel disease; ILC: Innate lymphoid cell; IFN: interferon; TNF: Tumor necrosis factor; NK: Natural killer.

Citation: Wallace KL, Zheng LB, Kanazawa Y, Shih DQ. Immunopathology of inflammatory bowel disease. World J Gastroenterol 2014; 20(1): 6-21
URL: https://www.wjgnet.com/1007-9327/full/v20/i1/6.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i1.6