Proliferating cell nuclear antigen and P53 protein expression and prognosis in primary liver cancer

Table 1 Proliferating cell nuclear antigen labeling index and tumor size

	Cases	PCNA labeling index
		Low index (+, ++)	High index (+++, ++++)
Small tumor	47	32	15a
Large tumor	152	88	65a

^aP > 0.05, small tumor vs large tumor. PCNA: Proliferating cell nuclear antigen.

Table 2 P53 expression and tumor size

	Cases	P53 expression
		Low expression (-, ++)	Overexpression (++,+++)
Small tumor	47	31	16a
Large tumor	153	90	63a

^aP > 0.05, small tumor vs large tumor.

Table 3 Proliferating cell nuclear antigen labeling index and tumor recurrence

	Cases	PCNA labeling index
		Low index (+, ++)	High index (+++, ++++)
Recurrence	38	11	27e
No recurrence	96	42	26e

^eP > 0.001, recurrence vs no recurrence. PCNA: Proliferating cell nuclear antigen.

Table 4 p53 expression and tumor recurrence

	Cases	p53 expression
		Low expression (-, ++)	Overexpression (++, +++)
Recurrence	38	17	21e
No recurrence	96	64	32e

^eP > 0.001, recurrence vs no recurrence.

Table 5 Comparison of the survival rates of patients with low or high labeling index of proliferating cell nuclear antigen after palliative hepatectomy

PCNA index	Cases	Survival rate (%)
		6 mo	12 mo	18 mo	Median time
Low index (+, ++)	39	89.7	76	69	14
High index (+++, ++++)	27	50.9	11.8	3.9	5

PCNA: Proliferating cell nuclear antigen.

Table 6 Comparison of the survival rates of patients with weak expression or overexpression P53 after palliative hepatectomy

PCNA index	Cases	Survival rate (%)
		6 mo	12 mo	18 mo	Median time
Low index (-, ++)	39	81.4	63.5	55.3	11
High index (++, +++)	27	52.9	11.8	5.9	6

P = 0.0079, Mantel-cox; P = 0.0051 Breslow. PCNA: Proliferating cell nuclear antigen