Effects of acute hepatic damage on natriuresis and water excretion after acute normal saline loading in rats

Table 1 Lesion indices of hepatic tissue and liver dysfunction after CCl₄ administration (n = 6, x^-± s)

Group	Water content (%)	ALT (Reitman U)	Caf t1/2 (min)
Control	70.1 ± 1.1	37.5 ± 12.6	94.8 ± 18.9
CCl4 24 h	73.0 ± 1.0b	189.4 ± 34.4b	326.4 ± 85.8b
CCl4 48 h	72.0 ± 0.8b	126.1 ± 59.1a	169.5 ± 37.9b

^aP < 0.05;

^bP < 0.01 vs control. Liver water content (%)

Table 2 Serum Na⁺ and water salt excretory rate (n = 6, x^-± s)

Group	serum Na+ (mmol/L)	Na+ excretory rate (%)	H2O excretory rate (%)
Control	145.7 ± 5.7	92.4 ± 14.1	86.3 ± 14.3
CCl4 24 h	143.0 ± 5.6	50.1 ± 13.1b	42.1 ± 8.8b
CCl4 48 h	139.8 ± 2.1	64.3 ± 14.1a	56.6 ± 12.4a

^aP < 0.05,

^bP < 0.01 vs control