Quantitative ultrastructure analysis of neuroendocrine cells of gastric mucosa in normal and pathological conditions

doi:10.3748/wjg.v2.i3.155

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Sep 15, 1996 (publication date) through Jan 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Articles

World J Gastroenterol. Sep 15, 1996; 2(3): 155-157
Published online Sep 15, 1996. doi: 10.3748/wjg.v2.i3.155

Table 1 Quantitative ultrastructure analysis of neuroendocrine cells of gastric mucosa in normal subjects

Cell type	Volume fraction (%)	Profiles/unit area (n/m²)	Cytoplasm composition (%)	Granule constituents (%)
Antrum
NE	1.6 ± 0.5
G	65.0 ± 2.0	2.4 ± 0.8	75.0 ± 3.0	16.0 ± 9.0
D	9.5 ± 0.6	0.3 ± 0.8	81.0 ± 4.0	35.0 ± 6.0
EC	8.6 ± 2.9	0.3 ± 0.7	76.0 ± 12.0	18.0 ± 7.0
Remaining cells	16.9 ± 3.2	0.6 ± 0.6	77.0 ± 8.0	3.8 ± 2.9
Corpus
NE	0.9 ± 0.4
ECL	30.0 ± 9.0	1.6 ± 0.7	70.0 ± 2.0	8.0 ± 2.0
EC	7.0 ± 5.0	0.3 ± 0.2	72.0 ± 13.0	16.0 ± 8.0
D	22.0 ± 4.0	1.5 ± 0.8	81.0 ± 7.0	31.0 ± 5.0
P	24.0 ± 7.0	0.8 ± 0.3	72.0 ± 7.0	6.0 ± 2.0
Remaining cells	17.6 ± 8.0	0.9 ± 0.5	68.0 ± 19.0	3.2 ± 2.6

Table 2 Quantitative ultrastructure analysis of neuroendocrine cells of the corpus mucosa in Zollinger-Ellison syndrome patients

Cell type	Volume fraction (%)	Profiles/unit area (n/m²)	Cytoplasm composition (%)	Granule constituents (%)
Antrum
NE	3.2 ± 1.1
ECL	65.0 ± 15.0^d	5.2 ± 2.4^c	82.0 ± 2.0^d	5.0 ± 2.0^c
EC	5.0 ± 2.0	0.7 ± 0.5	80.0 ± 13.0	6.0 ± 9.0^a
D	4.0 ± 4.0^d	0.6 ± 0.4	75.0 ± 14.0	18.0 ± 5.0^d
P	11.0 ± 8.0^a	1.1 ± 0.4	76.0 ± 7.0	3.0 ± 0.5^b
Remaining cells	10.0 ± 3.0	2.8 ± 1.5	78.0 ± 9.0	1.6 ± 0.8

^aP < 0.05;

^bP < 0.01;

^cP < 0.05;

^dP < 0.01

Table 3 Quantitative ultrastructure analysis of neuroendocrine cells of gastric mucosa in duodenal ulcer patients

Cell type	Volumefraction (%)	Profiles/unitarea (n/m²)	Cytoplasmcomposition (%)	Granuleconstituents (%)
Antrum
NE	1.3 ± 0.2
G	46.0 ± 2.0	1.8 ± 0.7	71.0 ± 3.0	16.0 ± 9.0
D	3.0 ± 1.6^a	0.1 ± 0.8^b	87.0 ± 4.0^a	28.0 ± 12.0
EC	16.0 ± 6.5	0.6 ± 0.7^b	77.0 ± 12.0	12.0 ± 5.0
Remaining cells	35.0 ± 13.0	1.2 ± 1.5	81.0 ± 8.0	3.8 ± 2.9
Corpus
NE	0.8 ± 0.3
ECL	49.0 ± 16.0^a	1.7 ± 1.0	70.0 ± 5.0	5.0 ± 2.0^a
EC	4.0 ± 2.0	0.3 ± 0.2	72.0 ± 24.0	8.0 ± 8.0
D	2.0 ± 4.0^a	0.3 ± 0.3^c	93.0 ± 6.0^a	33.0 ± 4.0
P	25.0 ± 4.0	1.7 ± 1.0	67.0 ± 5.0	3.0 ± 1.0
Remaining cells	20.0 ± 12.0	1.9 ± 1.5	81.0 ± 9.0	3.2 ± 2.8

^aP < 0.05;

^bP < 0.01;

^cP < 0.05

Citation: Yu JY, Adda T. Quantitative ultrastructure analysis of neuroendocrine cells of gastric mucosa in normal and pathological conditions. World J Gastroenterol 1996; 2(3): 155-157
URL: https://www.wjgnet.com/1007-9327/full/v2/i3/155.htm
DOI: https://dx.doi.org/10.3748/wjg.v2.i3.155