Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: A meta-analysis

Table 1 Characteristic of individual studies in the meta-analysis

Ref.	Year	Country/ethnicity	SNP of IL-10	IBS/controls	Genotyping methods	Diagnostic criteria	HWE of control
Gonsalkorale et al[21]	2003	United Kingdom	rs1800870	230/450	PCR-SSP	Rome I	0.000
van der Veek et al[13]	2005	Netherlands	rs1800870	111/128	PCR-RFLP	Rome II	0.707
Wang et al[24]	2006	China	rs1800870	43/41	PCR-RFLP	Rome II	0.678
Barkhordari et al[18]	2010	Iran	rs1800870	70/140	PCR-SSP	Rome III	0.041
Lee et al[22]	2010	South Korea	rs1800870	94/88	PCR-RFLP	Rome III	0.707
Santhosh et al[23]	2010	Indian	rs1800870	23/20	PCR-SSP	Rome II	0.717
Romero-Valdovinos et al[20]	2012	Mexico	rs1800870	45/173	PCR-RFLP	Rome III	0.000
Wang et al[24]	2006	China	rs1800871	43/41	PCR-RFLP	Rome II	0.619
Barkhordari et al[18]	2010	Iran	rs1800871	70/140	PCR-SSP	Rome III	0.907
Santhosh et al[23]	2010	China	rs1800871	23/20	PCR-SSP	Rome II	0.662
Romero-Valdovinos et al[20]	2012	Mexico	rs1800871	45/173	PCR-RFLP	Rome III	0.920
Wang et al[24]	2006	China	rs1800872	43/41	ARMS-PCR	Rome II	0.619
Barkhordari et al[18]	2010	Iran	rs1800872	70/140	PCR-RFLP	Rome III	0.97
Jiang et al[32]	2010	China	rs1800872	312/325	PCR-SSP	Rome III	0.255
Santhosh et al[23]	2010	Indian	rs1800872	23/20	PCR-SSP	Rome II	0.438
Romero-Valdovinos et al[20]	2012	Mexico	rs1800872	45/173	PCR-RFLP	Rome III	0.018

SNP: Single nucleotide polymorphism; HWE: Hardy-Weinberg equilibrium; IBS: Irritable bowel syndrome; PCR: Polymerase chain reaction; SSP: Sequence specific primer; RFLP: Restriction fragment length polymorphism; ARMS: Amplification refractory mutation system.

Table 2 Summary odds ratios of polymorphisms with irritable bowel syndrome risk

	P value	OR (95%CI)	I2	P heterogeneity	Begg’ test	Egger test
rs1800870
GG vs AA	0.338	1.11 (0.89-1.39)	0.0%	0.950	1.000	0.694
Caucasian[13,18,20,21]	0.228	1.19 (0.90-1.58)	0.0%	0.776
Asian[22-24]	0.963	1.01 (0.71-1.42)	0.0%	0.999
GG+GA vs AA	0.018	0.80 (0.66-0.96)	79.4%	0.000	1.000	0.200
Caucasian	0.003	0.70 (0.55-0.89)	88.5%	0.000
Asian	0.860	1.03 (0.74-1.43)	0.0%	0.990
AA+GA vs GG	0.007	0.68 (0.52-0.90)	0.0%	0.542	1.000	0.899
Caucasian	0.008	0.69 (0.52-0.91)	0.0%	0.415
Asian	0.478	0.31 (0.01-7.76)	-	-
G vs A	0.815	1.01 (0.90-1.14)	0.0%	0.720	0.764	0.773
Caucasian	0.799	1.02 (0.89-1.16)	17.1%	0.306
Asian	0.976	1.00 (0.80-1.260	0.0%	0.974
rs1800871
AA vs GG	0.698	0.90 (0.53-1.54)	0.0%	0.440	0.308	0.326
Caucasian[18,20]	0.205	0.56 (0.23-1.37)	22.6%	0.255
Asian[23,24]	0.530	1.25 (0.62-2.54)	0.0%	0.969
AA+GA vs GG	0.969	0.99 (0.61-1.60)	32.4%	0.218	0.308	0.146
Caucasian	0.182	0.58 (0.26-1.29)	0.0%	0.365
Asian	0.252	1.45 (0.77-2.76)	0.0%	0.364
GG+GA vs AA	0.651	0.92 (0.64-1.33)	0.0%	0.720	0.734	0.080
Caucasian	0.985	1.00 (0.68-1.49)	0.0%	0.906
Asian	0.219	0.54 (0.20-1.45)	0.0%	0.967
A vs G	0.496	1.09 (0.85-1.38)	0.0%	0.809	1.000	0.924
Caucasian	0.939	1.01 (0.75-1.37)	0.0%	0.631
Asian	0.314	1.23 (0.83-1.82)	0.0%	0.671
rs1800872
CC vs AA	0.989	1.00 (0.77-1.19)	0.0%	0.456	0.806	0.506
Caucasian[18,20]	0.379	0.73 (0.37-1.47)	41.6%	0.191
Asian[23,24,32]	0.730	1.05 (0.80-1.38)	0.0%	0.466
CC+CA vs AA	0.028	1.29 (1.03-1.62)	0.0%	0.717	0.221	0.196
Caucasian	0.417	1.27 (0.71-2.26)	0.0%	0.573
Asian	0.042	1.29 (1.01-1.66)	0.0%	0.410
AA+CA vs CC	0.833	0.97 (0.72-1.31)	60.2%	0.040	0.806	0.384
Caucasian	0.578	1.13 (0.72-1.71)	3.2%	0.310
Asian	0.382	0.82 (0.53-1.27)	76.0%	0.016
C vs A	0.112	1.12 (0.97-1.28)	0.0%	0.863	0.086	0.266
Caucasian	0.614	1.12 (0.97-1.28)	0.0%	0.669
Asian	0.114	1.14 (0.97-1.33)	0.0%	0.618