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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2013; 19(48): 9432-9438
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9432
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9432
Table 1 Clinical characteristics of the study population at admission
Parameter | ACLF (n = 56) | CHB (n = 30) | Control (n = 30) |
Male/female | 40/16 | 21/9 | 14/6 |
Age (yr) | 44 ± 11 | 40 ± 10 | 39 ± 8 |
Alanine aminotransferase (IU/L) | 145 ± 189 | 71 ± 61 | 21 (10-31) |
Total bilirubin (mg/dL) | 20.2 ± 5.6 | 2.2 ± 1.3 | 0.7 ± 0.2 |
Albumin (g/L) | 30.4 ± 4.8 | 33.5 ± 5.2 | 35.6 ± 4.9 |
BUN (mmol/L) | 4.4 ± 2.1 | 4.1 ± 1.8 | 4.8 ± 1.5 |
Plasma sodium (mEq/L) | 134.8 ± 4.5 | 135.6 ± 5.7 | 137.4 ± 3.8 |
Cr (mg/dL) | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 |
CysC (mg/L) | 1.1 ± 0.4 | 0.7 ± 0.2 | 0.6 ± 0.3 |
International normalized ratio | 1.9 ± 0.4 | 1.1 ± 0.2 | 0.9 ± 0.1 |
HBV DNA log10 (IU/mL) | 4.75 ± 2.11 | 6.21 ± 2.78 | |
Ishak score | ND | 4 (3-5)1 | |
MELD score | 24 ± 3 | 8 ± 4 |
Table 2 Comparison of baseline clinical characteristics in patients with or without acute kidney injury during hospitalization
Parameter | Without AKI (n = 48) | With AKI (n = 8) | P (univariate) | P (multivariate) | OR (95%CI) |
Age (yr) | 41 ± 9 | 55 ± 7 | < 0.001 | ||
Alanine aminotransferase (IU/L) | 156 ± 158 | 62 ± 40 | 0.202 | ||
Albumin (g/L) | 30.1 ± 5.1 | 30.2 ± 2.1 | 0.965 | ||
BUN (mmol/L) | 4.2 ± 2.0 | 5.7 ± 1.1 | 0.065 | ||
Sodium (mEq/L) | 135.3 ± 4.2 | 132.1 ± 3.8 | 0.064 | ||
Total bilirubin (mg/dL) | 19.8 ± 5.6 | 21.3 ± 4.9 | 0.506 | ||
Cr (mg/dL) | 0.9 ± 0.1 | 1.0 ± 0.2 | 0.792 | ||
International normalized ratio | 1.9 ± 0.4 | 2.0 ± 0.3 | 0.367 | ||
MELD score | 24 ± 3 | 26 ± 2 | 0.094 | ||
CysC (mg/L) | 0.9 ± 0.3 | 1.8 ± 0.4 | < 0.001 | 0.021 | 1.8 (1.4–2.3) |
Table 3 Area under the curve for receiver operating characteristics and cutoff values for predicting acute kidney injury in acute-on-chronic liver failure patients
Parameter | Cutoff value | AUC (95%CI) | Sensitivity | Specificity | P value |
CysC (mg/L) | 1.21 | 0.974 (0.846-1.000) | 100% | 87.5% | < 0.0001 |
Cr (mg/dL) | 1.1 | 0.526 (0.343-0.704) | 37.5% | 91.7% | 0.828 |
BUN (mmol/L) | 4.9 | 0.674 (0.487-0.829) | 62.5% | 79.2% | 0.124 |
Serum sodium (mEq/L) | 131 | 0.687 (0.500-0.839) | 50% | 87.5% | 0.113 |
- Citation: Wan ZH, Wang JJ, You SL, Liu HL, Zhu B, Zang H, Li C, Chen J, Xin SJ. Cystatin C is a biomarker for predicting acute kidney injury in patients with acute-on-chronic liver failure. World J Gastroenterol 2013; 19(48): 9432-9438
- URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9432.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9432