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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2013; 19(48): 9328-9333
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9328
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9328
Table 1 Baseline characteristics of hepatocellular carcinoma cases
HCV Ab(+), HCV RNA(+) (n = 108) | HCV Ab(+) (n = 77) | P value | |
Age (yr), mean ± SD | 60.88 ± 8.6 | 59.42 ± 7.4 | 0.88 |
Males | 73.10% | 67.53% | 0.32 |
African American | 75.90% | 72.70% | 0.22 |
n = 70 | n = 52 | 0.20 | |
BMI (kg/m2) | 29.56 ± 6.11 | 27.88 ± 5.2 | |
HIV coinfection | 10.20% | 7.60% | 0.16 |
Heavy alcohol use | 37.03% | 48.05% | 0.04 |
Table 2 Comparison of variables in cases and controls
CHC with HCC (n = 185) | CHC without HCC (n = 356) | P value | |
Age (yr), mean ± SD | 60.3 ± 9.71 | 59.72 ± 9.2 | |
Males | 70.80% | 71.10% | |
Race AA | 74.60% | 78.70% | |
CAU | 21.60% | 18.50% | |
Other | 3.80% | 2.80% | |
BMI (kg/m2) | n = 122 | n = 320 | |
28.8 ± 6.01 | 27.26 ± 5.9 | ||
Albumin | n = 178 | n = 289 | |
2.67 ± 0.7 | 3.88 ± 0.6 | < 0.01 | |
PT (s) | n = 171 | n = 242 | |
16.69 ± 8.6 | 11.57 ± 2.5 | < 0.01 | |
AFP (ng/mL) | n = 163 | n = 284 | |
99035.1 ± 263605.5 | 21.12 ± 90.4 | ||
Platelets | n = 172 | n = 337 | |
176.5 ± 127 | 202.98 ± 83.4 | 0.04 | |
ALT (IU/L) | n = 166 | n = 345 | |
263.8 ± 518.2 | 78.19 ± 58.3 | < 0.01 | |
AST (IU/L) | n = 160 | n = 324 | |
283.8 ± 63.5 | 75.2 ± 55.9 | < 0.01 | |
HIV co-infection | 8.10% | 2.50% | 0.05 |
Alcohol | |||
Mild | 29.7% | 27.50% | NS |
Heavy | 41.60% | 27% | 0.03 |
Non drinkers | 10.80% | 31.70% | < 0.01 |
Table 3 Univariate analysis predicting the following
OR (95%CI) | P value | |
HCC in patients with CHC | ||
HBcAb(+) | 1.90 (1.28-3.04) | 0.02 |
HBsAb(-) and HBcAb(+) | 3.24 (2.28-4.62) | < 0.01 |
HCC in cirrhotic patients with CHC | ||
HBcAb(+) | 1.54 (1.18-2.54) | 0.02 |
HBsAb(-) and HBcAb(+) | 2.14 (1.68-3.82) | 0.01 |
HCC in patients with CHC when controlled for covariates1 | ||
HBcAb(+) | 1.84 (1.22-3.08) | 0.01 |
HBsAb(-) and HBcAb(+) | 2.98 (2.12-5.08) | < 0.01 |
HCC in cirrhotic patients with CHC when controlled for covariates1 | ||
HBcAb(+) | 1.66 (1.22-3.24) | 0.01 |
HBsAb(-) and HBcAb(+) | 2.10 (1.72-4.04) | < 0.01 |
HCC in cirrhotic African American patients with CHC when controlled for covariates1 | ||
HBcAb(+) | 2.08 (1.42-3.6) | < 0.01 |
HBsAb(-) and HBcAb(+) | 2.58 (1.82-4.44) | < 0.01 |
- Citation: Reddy A, May E, Ehrinpreis M, Mutchnick M. Latent hepatitis B is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C. World J Gastroenterol 2013; 19(48): 9328-9333
- URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9328.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9328