Long-term survival after liver transplantation for alcoholic liver disease

Table 1 Primary indication for liver transplantation in Europe and the corresponding survival

Indication for LT	Patients (n)	From 1988 to 2009
		1 yr	5 yr	10 yr
Alcoholic cirrhosis	15019	86%	73%	59%
Acute hepatic failure	6507	70%	64%	58%
Cirrhosis virus C	10753	80%	65%	53%
Cirrhosis viral C and alcoholic	1790	85%	69%	54%
Cirrhosis virus B	4187	83%	74%	68%
Hepatocarcinoma and cirrhosis	9122	83%	62%	49%
Cholestatic disease	9114	87%	78%	70%
Autoimmune cirrhosis	1892	85%	76%	67%
Hemochromatosis	468	76%	66%	53%

Adapted from the European Liver Transplant Registry[3]. LT: Liver transplantation.

Table 2 Alcohol relapse (any use) after liver transplantation for alcohol liver disease

Ref.	Study design	Patients (n)	Year	Follow-up median or mean (mo)	Relapse rate
Bird [34]	Retrospective	18	1990	84	17%
Kumar et al[48]	Retrospective	52	1990	25	12%
Gish et al[42]	Prospective	29	1993	24	24%
Knechtle et al[38]	Retrospective	32	1993	Not stated	13%
Berlakovich et al[22]	Retrospective	44	1994	78	32%
Howard et al[45]	Retrospective	20	1994	43	95%
Krom et al[48]	Retrospective	30	1994	Not stated	13%
Osorio et al[51]	Retrospective	43	1994	21	19%
Gerhardt et al[41]	Retrospective	41	1996	47	49%
Tringali et al[56]	Retrospective	58	1996	27	21%
Zibari et al[58]	Retrospective	29	1996	Not stated	7%
Coffman et al[84]	Prospective	91	1997	Not stated	20%
Anand et al[31]	Retrospective	39	1997	25	13%
Everson et al[38]	Retrospective	42	1997	Not stated	17%
Foster et al[40]	Retrospective	63	1997	49	21%
Lucey et al[50]	Retrospective	50	1997	63	34%
Stefanini et al[53]	Retrospective	18	1997	Not stated	27%
Fabrega et al[39]	Prospective	44	1998	40	18%
Tang et al[54]	Retrospective	56	1998	24	50%
Yates et al[57]	Retrospective	43	1998	21	19%
Gledhill et al[44]	Retrospective	24	1999	14	25%
Pageaux et al[75]	Retrospective	53	1999	32	42%
Pereira et al[13]	Retrospective	56	2000	30	50%
Burra et al[73]	Prospective	34	2000	40	33%
Jain et al[79]	Retrospective	185	2000	94	20%
Dimartini et al[37]	Prospective	36	2001	12	38%
Gish et al[43]	Prospective	61	2001	83	20%
Mackie et al[28]	Retrospective	46	2001	25	53%
Bellamy et al[32]	Retrospective	123	2001	84	13%
Karman et al[57]	Retrospective	49	2001	36	21%
Bravata et al[93]	Retrospective	313	2001	Not stated	32%
Pageaux et al[52]	Retrospective	128	2003	54	31%
Jauhar et al[86]	Retrospective	111	2004	44	15%
Cuadrado et al[36]	Retrospective	54	2005	99	26%
Bjornsson et al[35]	Retrospective	103	2005	31	33%
Kelly et al[85]	Retrospective	90	2006	67	31%
Pfitzman et al[83]	Retrospective	300	2007	89	19%
Karim et al[91]	Retrospective	80	2010	Not stated	10%
Schmeding et al[60]	Retrospective	300	2011	84	27%
Rice et al[74]	Retrospective	300	2013	78	16%