Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review

Table 1 Characteristics of the included studies

Ref.	Year	n	Male (%)	Mean age	BMI	Study design	Treatment agent (daily), dose	Treatment duration	Outcome measures
Trials comparing mosapride plus PPI combined therapy with PPI monotherapy
Madan et al[15]/ India	2004	Cases 33	57.6	34.7	Unclear	Double-blind	Pantoprazole 80 mg	8 wk	Symptom
		Controls 28	75.0	36.5	Unclear	Randomized	+ mosapride 15 mg		Questionnaire
						controlled trial	Pantoprazole 80 mg + placebo
Hsu et al[35]/Taiwan	2010	Cases 50	46.0	47.0	23.7 ± 3.6	Double-blind	Lansoprazole 30 mg	4 wk	FSSG
		Controls 46	54.3	47.0	23.9 ± 4.6	Randomized	+ mosapride 15 mg		Questionnaire
						Crossover trial	Lansoprazole 30 mg + placebo
Miwa et al[16]/Japan	2011	Cases 97	38.1	52.1	22.3 ± 3.3	Double-blind	Omeprazole 10 mg	4 wk	VAS
		Controls 95	36.8	52.2	22.0 ± 3.6	Randomized	+ mosapride 15 mg
						Controlled trial	Omeprazole 10 mg + placebo
Cho et al[36]/ South Korea	2012	Cases 24	62.5	49.0	21.3 ± 2.3	Double-blind	Esomeprazole 40 mg	4 wk	Reflux-symptoms
		Controls 19	47.4	43.0	21.5 ± 2.3	Randomized	+ mosapride 30 mg		Questionnaire
						Controlled trial	Esomeprazole 40 mg + placebo
Trials on addition of mosapride to PPIs for the treatment of PPI-resistant GERD patients
Miyamoto et al[37]/ Japan	2008	34	Unclear	53.11	23.0 ± 0.31	Open trial	Rabeprazole 10 mg	12 wk	FSSG
							+ mosapride 15 mg		Questionnaire
Futagami et al[38]/ Japan	2010	44	50%	42.8	23.0 ± 1.9	Open trial	Omeprazole 20 mg	12 wk	GSRS
							+ mosapride 15 mg		Questionnaire
Miyamoto et al[39]/ Japan	2010	117	Unclear	47.41	23.0 ± 3.61	Open trial	PPI therapy2	4 wk	FSSG
							+ mosapride 15 mg		Questionnaire

¹Data calculated based on the included participants at the beginning of study;

²Patients were randomly administered rabeprazole 10 mg or lansoprazole 30 mg or omeprazole 20 mg or lansoprazole 15 mg or omeprazole 10 mg. PPI: Proton pump inhibitor; GERD: Gastrooesophageal reflux disease; FSSG: Frequency scale for the symptoms of GERD; GSRS: Gastrointestinal symptom rating scale; VAS: Visual analogue scale; BMI: Body mass index.