Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine

Table 1 Weight at the beginning of the treatment and after caffeine treatment, serum markers enzymes in bile duct ligation and thioacetamide-intoxicated rats

Group	Healthy	TAA	TAA + CFA	BDL	BDL + CFA
Rats weight at the beginning of the treatment (g)	296.0 ± 9.73	284.0 ± 22.1	282.2 ± 9.1	280.1 ± 18.3	275.0 ± 19.0
Rats weight after CFA treatment (g)	321.0 ± 8.5	223.1 ± 14.0b	253.7 ± 5.7	219.4 ± 15.3	221.0 ± 17.5
AST (U/L)	226.0 ± 61.0	379.7 ± 179.8	318.2 ± 144.3	576.7 ± 70.0	329.5 ± 41.4c
ALT (U/L)	63.0 ± 1.0	132.7 ± 7.5	98.2 ± 28.7	214.7 ± 37.0	76.0 ± 10.6d

Treatment duration: 7 wk for thioacetamide (TAA) and 4 wk for bile duct ligation (BDL).

^bP < 0.01 vs TAA group;

^cP < 0.05,

^dP < 0.01 vs BDL group. Data are shown as the mean ± SD (n = 10). CFA: Caffeine; AST: Aspartate transaminase; ALT: Alanine transaminase.