Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany

Table 1 Incidence of gastroenteropancreatic neuroendocrine tumors according to anatomic site, sex, and the time periods 1976-1988 and 1998-2006

Period	Stomach (M/F)1	Small intestine (M/F)1	Pancreas (M/F)1	Appendix (M/F)1	Colon (M/F)1	Rectum (M/F)1
1976-1978	0.02/0.00	0.11/0.15	0.03/0.08	0.20/0.35	0.04/0.05	0.01/0.01
1979-1981	0.04/0.03	0.10/0.11	0.07/0.014	0.15/0.34	0.04/0.07	0.01/0.03
1982-1984	0.04/0.04	0.16/0.12	0.11/0.08	0.15/0.35	0.04/0.07	0.03/0.02
1985-1988	0.05/0.04	0.20/0.18	0.10/0.10	0.24/0.35	0.08/0.15	0.03/0.07
1989-1997
1998-2000	0.16/0.12	0.39/0.31	0.22/0.18	0.13/0.28	0.19/0.19	0.09/0.10
2001-2003	0.18/0.18	0.44/0.40	0.25/0.25	0.23/0.46	0.22/0.23	0.16/0.15
2004-2006	0.27/0.23	0.51/0.52	0.25/0.25	0.31/0.39	0.20/0.28	0.26/0.24

¹Male/female (M/F) patients. Incidence rates were age-adjusted to the German standard population of 1987. The data shown originate from the former East German National Cancer Registry (DDR Krebsregister) for the years 1976-1988 or from its successor, the Joint Cancer Registry for the time period 1998-2006. No valid data are available for the period between 1989 and 1997.

Table 2 1-, 5- and 10-year overall survival of patients with gastroenteropancreatic neuroendocrine tumors

Overall survival/period	Stomach	Small intestine	Pancreas	Appendix	Colon	Rectum
1-yr/1976-1988	22%	30%	26%	95%	35%	50%
5-yr/1976-1988	11%	18%	11%	92%	16%	37%
10-yr/1976-1988	5%	10%	8%	90%	13%	37%
1-yr/1998-2006	71%	85%	74%	95%	68%	74%
5-yr/1998-2006	53%	68%	52%	86%	48%	65%
10-yr/1998-2006	43%	53%	35%	81%	34%	50%

Data are given for different primary tumor sites and two periods of time (1976-1988 and 1998-2006).