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World J Gastroenterol. Dec 14, 2013; 19(46): 8758-8763
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8758
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8758
Indonesia | H. pylori (+)n= 33 | H. pylori (-)n= 261 |
Sex | ||
Male | 9 (8.4) | 98 (91.6) |
Female | 24 (12.8) | 163 (87.2) |
Age, yr | ||
≤ 30 | 12 (9.6) | 113 (90.4) |
31-40 | 9 (11.5) | 69 (88.5) |
41-50 | 7 (14.6) | 41 (85.4) |
51-60 | 3 (9.4) | 29 (90.6) |
≥ 60 | 2 (18.2) | 9 (81.8) |
Mean age, yr | 36.3 ± 14.6 (SD) | 33.7 ± 14.4 (SD) |
Polymorphism | H. pylori (+)n= 33 | H. pylori (-)n= 261 | OR1 | 95%CI1 |
IL-1β T-31C | ||||
TT | 8 (24.2) | 59 (22.6) | ref | |
CC | 8 (24.2) | 73 (28.0) | 0.82 | 0.29-2.32 |
TC | 17 (51.5) | 129 (49.4) | 1.05 | 0.42-2.59 |
TC/CC | 25 (75.8) | 202 (77.4) | 0.96 | 0.41-2.26 |
IL-4 T-33C | ||||
TT | 15 (45.5) | 128 (49.0) | ref | |
CC | 2 (6.1) | 19 (7.3) | 0.83 | 0.17-3.99 |
TC | 16 (48.5) | 114 (43.7) | 1.24 | 0.58-2.64 |
CC/TC | 18 (54.5) | 133 (51.0) | 1.18 | 0.56-2.45 |
IL-8 T-251A | ||||
TT | 14 (42.4) | 98 (37.6) | ref | |
AA | 8 (24.2) | 49 (18.8) | 1.25 | 0.48-3.27 |
TA | 11 (33.3) | 114 (43.7) | 0.74 | 0.32-1.72 |
TA/AA | 19 (57.6) | 163 (62.5) | 0.89 | 0.42-1.88 |
CD14 C-159T | ||||
CC | 7 (21.2) | 65 (24.9) | ref | |
TT | 8 (24.2) | 65 (24.9) | 1.09 | 0.37-3.20 |
CT | 18 (54.6) | 131 (50.2) | 1.26 | 0.50-3.19 |
CT/TT | 26 (78.8) | 196 (75.1) | 1.2 | 0.50-2.92 |
TNF-α T-1031C | ||||
TT | 11 (33.3) | 120 (46.0) | ref | |
CC | 6 (18.2) | 36 (13.8) | 1.99 | 0.67-5.89 |
TC | 16 (48.5) | 105 (40.2) | 1.66 | 0.73-3.76 |
CC/TC | 22 (66.7) | 141 (54.0) | 1.74 | 0.80-3.76 |
PTPN11 G/A at intron 3 | ||||
GG | 17 (51.5) | 151 (57.9) | ref | |
AA | 1 (3.0) | 17 (6.5) | 0.6 | 0.07-4.86 |
GA | 15 (45.5) | 93 (35.6) | 1.49 | 0.70-3.15 |
GA/AA | 16 (48.5) | 110 (42.2) | 1.37 | 0.65-2.85 |
Allele | H. pylori (+)n= 66 | H. pylori (-)n= 522 | OR1 | 95%CI |
IL-1β T-31C | ||||
T | 33 (50.0) | 247 (47.3) | ref | |
C | 33 (50.0) | 275 (52.7) | 1.10 | 0.70-1.73 |
IL-4 T-33C | ||||
T | 46 (69.7) | 370 (70.9) | ref | |
C | 20 (30.3) | 152 (29.1) | 0.95 | 0.58-1.56 |
IL-8 T-251A | ||||
T | 39 (59.1) | 310 (59.4) | ref | |
A | 27 (40.9) | 212 (40.6) | 0.99 | 0.62-1.57 |
CD14 C-159T | ||||
C | 32 (48.5) | 261 (50.0) | ref | |
T | 34 (51.5) | 261 (50.0) | 0.95 | 0.60-1.49 |
TNF-α T-1031C | ||||
T | 38 (57.6) | 345 (66.1) | ref | |
C | 28 (42.4) | 177 (33.9) | 0.73 | 0.46-1.15 |
PTPN11 G/A at intron 3 | ||||
G | 49 (74.2) | 395 (75.7) | ref | |
A | 17 (25.8) | 127 (24.3) | 0.94 | 0.56-1.57 |
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Citation: Zhao Y, Wang JW, Tanaka T, Hosono A, Ando R, Tokudome S, Soeripto, Triningsih FE, Triono T, Sumoharjo S, Achwan EWA, Gunawan S, Li YM. Association between
TNF-α andIL-1β genotypesvs Helicobacter pylori infection in Indonesia. World J Gastroenterol 2013; 19(46): 8758-8763 - URL: https://www.wjgnet.com/1007-9327/full/v19/i46/8758.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i46.8758