Clostridium difficile-associated disease: Adherence with current guidelines at a tertiary medical center

Table 1 Comparison of demographics, disease severity, and other clinical factors between guideline adherent and guideline non-adherent groups n (%)

	Guideline	Guideline	Unadjusted	Adjusted
	Compliant,	Non-compliant,	P value	P value
	n = 139	n = 181
Demographics
Mean ± SD, yr	56.8 ± 14.1	59.4 ± 16.2	0.13
Female	61 (44.2)	77 (55.8)	0.81
Disease severity
Mild-moderate	89 (65.9)	46 (34.1)	< 0.0011	< 0.0011
Severe	39 (25.3)	115 (74.7)
Severe-complicated	11 (35.5)	20 (64.5)
Severe + severe-complicated	50 (27.0)	135 (73.0)
Other factors
Hospitalized	133 (43.3)	174 (56.7)	0.84
ICU	60 (40.0)	90 (60.0)	0.24
Prior antibiotics (< 30 d)	88 (39.1)	137 (60.9)	0.02	0.08
Recurrence	17 (34.0)	33 (66.0)	0.14	0.04
Immunosuppressed	57 (51.8)	53 (49.2)	0.03	0.49
30-d mortality	15 (41.7)	21 (58.3)	0.82

¹On unadjusted analysis, mild-moderate disease is compared to both severe and severe complicated disease. On adjusted analysis, mild-moderate disease is compared to the combination of severe and severe-complicated disease.